Results 51 to 60 of about 670,599 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spark ultrasonic transducer [PDF]

, 1972
Nondestructive testing by spark transducer induces ultrasonic pulses in materials without physical contact. High power pulse generator connected to step up transformer produces sparking between two tungsten rods and ultrasonic energy pulses in test ...
Hoop, J. M.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Continuous monitoring of an intentionally-manufactured crack using an automated welding and in-process inspection system

Materials & Design, 2020
Automated weld deposition coupled with the real-time robotic Non-Destructive Evaluation (NDE) is used in this paper. For performance verification of the in-process inspection system, an intentionally embedded defect, a tungsten rod, is introduced into ...
Yashar Javadi, Ehsan Mohseni, Charles N. MacLeod, David Lines, Momchil Vasilev, Carmelo Mineo, Euan Foster, Stephen G. Pierce, Anthony Gachagan   +8 more
doaj   +1 more source

Comparison between two ultrasonic methods in their ability to monitor the setting process of cement pastes [PDF]

, 2009
This paper presents the comparison between ultrasonic wave transmission (USWT) method and ultrasonic wave reflection (USWR) method in their ability to monitor the setting process of cement pastes.
Akkaya, Franci Kavčič, Goran Turk, Gregor Trtnik, Grosse, Hewlett, Kamada, Keating, Korhonen, Krauss, Marko Ivan Valič, Rapoport, Reinhardt, Robeyst, Sayers, Schindler, Stepišnik, Sun, Sun, Trtnik, Valič, Voigt, Voigt, Voigt   +23 more
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Conformal mapping of ultrasonic crystals: confining ultrasound and cochlear-like wave guiding

, 2007
Conformal mapping of a slab of a two-dimensional ultrasonic crystal generate a closed geometrical arrangement of ultrasonic scatterers with appealing acoustic properties. This acoustic shell is able to confine ultrasonic modes.
A. Bazán, F. R. Montero de Espinosa, J. L. Aragón, M. Torres, Nehari Z., R. Quintero-Torres   +5 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Ultrasonic evaluation of high voltage circuit boards [PDF]

Preliminary observations indicate that an ultrasonic scanning technique may be useful as a quick, low cost, nondestructive method for judging the quality of circuit board materials for high voltage applications.
Klima, S. J., Riley, T. J.
core   +2 more sources