Results 51 to 60 of about 79,314 (309)

Machine learning-based ultrasomics for predicting response to tyrosine kinase inhibitor in combination with anti-PD-1 antibody immunotherapy in hepatocellular carcinoma: a two-center study

Frontiers in Oncology
ObjectiveThe objective of this study is to build and verify the performance of machine learning-based ultrasomics in predicting the objective response to combination therapy involving a tyrosine kinase inhibitor (TKI) and anti-PD-1 antibody for ...
Yiwen Hu, Yiwen Hu, Linlin Zhang, Linlin Zhang, Qinghua Qi, Shanshan Ren, Shanshan Ren, Simeng Wang, Simeng Wang, Lanling Yang, Juan Zhang, Juan Zhang, Yuanyuan Liu, Yuanyuan Liu, Xiaoxiao Li, Xiaoxiao Li, Xiguo Cai, Shaobo Duan, Shaobo Duan, Shaobo Duan, Lianzhong Zhang, Lianzhong Zhang, Lianzhong Zhang, Lianzhong Zhang   +23 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The combined diagnostic and therapeutic value of ultrasound and X-ray bone age index in girls with idiopathic central precocious puberty

Endocrine Connections
Objectives: The objectives of this study are threefold: first, to evaluate the diagnostic utility of ultrasound in combination with radiographic bone age assessments for identifying idiopathic central precocious puberty (ICPP) in girls; second, to ...
Linli Kan, Deng He, Wensheng Yue
doaj   +1 more source

Laser Ultrasonic System for Surface Crack Visualization in Dissimilar Welds of Control Rod Drive Mechanism Assembly of Nuclear Power Plant

Shock and Vibration, 2014
In this paper, we propose a J-groove dissimilar weld crack visualization system based on ultrasonic propagation imaging (UPI) technology. A full-scale control rod drive mechanism (CRDM) assembly specimen was fabricated to verify the proposed system.
Yun-Shil Choi, Hyomi Jeong, Jung-Ryul Lee   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A SAFT Method for the Detection of Void Defect inside a Ballastless Track Structure Using Ultrasonic Array Sensors

Sensors, 2019
High-precision ultrasound imaging of void defects is critical for the performance and safety assessment of ballastless track structures. The sound propagation velocity of each layer in the ballastless track structure is quite different.
Wen-Fa Zhu, Xing-Jie Chen, Zai-Wei Li, Xiang-Zhen Meng, Guo-Peng Fan, Wei Shao, Hai-Yan Zhang   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy

Nature Communications, 2017
The state-of-the-art three-dimensional biomedical imaging often requires specific tissue preparation that may alter the physical properties of the specimen causing loss of information. Here Wong et al.
Terence T. W. Wong, Ruiying Zhang, Chi Zhang, Hsun-Chia Hsu, Konstantin I. Maslov, Lidai Wang, Junhui Shi, Ruimin Chen, K. Kirk Shung, Qifa Zhou, Lihong V. Wang   +10 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source