Results 191 to 200 of about 23,736 (254)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Large‐Area Noise‐Resilient Multiplexing Triboelectric Biomechanical Sensing on Clothing for High‐Precision Full‐Body Motion Capture in Wearables

Advanced Science, EarlyView.
A large‐area, noise‐resilient multiplexed triboelectric sensing garment based on a multilayer shielded architecture and SnS2 nanoflower‐engineered hybrid materials enables interference‐suppressed, high‐fidelity full‐body motion tracking, achieving 0.13% signal misrecognition, 57 dB electromagnetic noise attenuation, and >1.5 N threshold force, while ...
Beibei Shao, Ming‐Han Lu, Wei‐Chen Peng, Wei‐Chun Yang, Yi‐Ting Chen, Jiun‐Wei Fong, Tzu‐Ching Lu, Tai‐Chen Wu, Zhi‐Xian Yan, Kai‐Yuan Hsiao, Jiann‐Yeu Chen, Ming‐Yen Lu, Heng‐Jui Liu, Ruiyuan Liu, Ying‐Chih Lai   +14 more
wiley   +1 more source

Detection of Degraded Formulated BaTiO3 Induced by Oxygen Vacancy Migration Using Ultrasonic Attenuation

Advanced Science, EarlyView.
Oxygen vacancy migration is a key degradation mechanism for the majority of MLCCs. There are limitations with spatially identifying regions of a capacitor that have degraded due to oxygen vacancy migration. This work showcases ultrasonic attenuation as a non‐electrical and nondestructive technique of identifying oxygen vacancy degraded regions of an ...
Haley N. Jones, Clive A. Randall, Andrea P. Argüelles, Susan Trolier‐McKinstry   +3 more
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

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Ultrasonic Aspiration Transducer

Radiology, 1972
Fluid-containing structures can be localized and aspirated by using a specially-designed ultrasonic transducer with a central hole. A needle is directed through the hole and into the tissue. The path of the needle tip can be followed ultrasonically as it enters the fluid. The same transducer is used to monitor the procedure continuously while the fluid
B B, Goldberg, H M, Pollack
openaire   +2 more sources

Optimization of ultrasonic transducers

Ultrasonics, 1985
The so-called KLM-model for ultrasonic transducers is employed to optimize transducer design. Some new performance characteristics are defined which change monotonically with design parameters. These characteristics are based on the area of the envelope of the echo waveform produced by the transducer and of the corresponding amplitude spectrum.
J M, Thijssen, W A, Verhoef, M J, Cloostermans   +2 more
openaire   +2 more sources

Micromachined Ultrasonic Transducers

2008
In this chapter the basic principles, the fabrication process, and some modelling approaches of the novel micromachined ultrasonic transducers (MUTs) are described. These transducers utilize the flex-tensional vibration of an array of micro membranes. They are usually called cMUT (capacitive Micromachined Ultrasonic Transducer) or pMUT (piezoelectric ...
Pappalardo M, CALIANO, Giosue', SAVOIA, ALESSANDRO STUART, Caronti A.   +3 more
openaire   +2 more sources

Ultrasonic wave transducer system and ultrasonic wave transducer

The Journal of the Acoustical Society of America, 2003
There is disclosed an ultrasonic transducer system for harmonic imaging, comprising: an ultrasonic transducer comprising a transmitting ultrasonic vibrator for transmitting a fundamental ultrasound having a center frequency f0, and a receiving ultrasonic vibrator for receiving a harmonic signal having a center frequency nf0 (n is an integer of 2 or ...
Hideo Adachi, Katsuhiro Wakabayashi
openaire   +1 more source

Ultrasonic transducer, method for manufacturing ultrasonic transducer, and ultrasonic flowmeter

The Journal of the Acoustical Society of America, 2007
It is an object of the present invention to provide an ultrasonic transducer, which is so configured as to reduce the variations in characteristics, thereby to enable the stabilization of the precision, as well as to enable the improvement of the durability, and the like, a method for manufacturing the ultrasonic transducer, and an ultrasonic flowmeter.
openaire   +1 more source