Results 161 to 170 of about 135,815 (306)

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source

Ultrastructure of Vitellogenic Ovarian Follicles and Morphogenesis of the Oocyte Envelope in the Eurasian Ruffe (Gymnocephalus cernua Linnaeus 1758) (Teleostei, Perciformes). [PDF]

J Morphol
Żelazowska M, Kujawa R.
europepmc   +1 more source

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

SynAtlas: A Safe and Versatile Platform for Rapid Organ‐Scale Tissue Clearing and 3D Atlas Mapping

Advanced Science, EarlyView.
An orthogonal synergy design principle integrates lipid solubilization, protein hydration modulation, and refractive‐index matching within a unified aqueous clearing system. This modular strategy enables rapid, low‐hazard, and broadly compatible tissue clearing while preserving molecular signals, supporting multiscale three‐dimensional imaging across ...
Mei‐Xue Yuan, Xin‐Ya Qin, Ling‐Jie Li, Kai‐Lang Xiao, Meng‐Meng Zhang, Kun‐Qi Chen, Peng Chen, Yu Wang, Chen‐Wei Wang, Nan Zhou, Qing‐Hong Shan   +10 more
wiley   +1 more source

FoxO3a-Smad4 Co-localization and Autophagy Alterations are Associated with Cognitive Impairment in Alcohol-Dependent Rats Fed a High-Fat Diet. [PDF]

Neurochem Res
He S, Ren Y, Jiang Q, Dong Y, Li F, Ren J, Song Q, Zhao J, Yin C, Zhao W.   +9 more
europepmc   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Correction: Pregnancy and lactation exposure to bisphenol S induces ferroptosis via disrupted hepatic lipid metabolism in offspring mice. [PDF]

Front Toxicol
Pan M, Guo X, Wei C, Xu N, Su Y, Ma Z, Zeng H.   +6 more
europepmc   +1 more source

Automated Bacterial Identification and Morphological Feature Analysis in Low‐Dose Cryo‐EM Using YOLOv11

Advanced Intelligent Discovery, EarlyView.
AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula, Lynnicia N. Massenburg, Spenser R. Brown, Amber N. Bible, Chanda R. Harris, Lance X. Zhang, Kiara Parker, Scott T. Retterer, Jennifer L. Morrell‐Falvey, Rama K. Vasudevan, Alexis N. Williams   +10 more
wiley   +1 more source

Ultrastructure of the Developing Sunflower Microscope

, 1977
An investigation of the ultrastructure revealed that most of the mitochondria of the microspore and mononuclear pollen grain of the sunflower are situated on the surface of the outer membrane of the nuclear envelope, frequently in direct contact with ...
Simonenko, V. K.
core  

Correction to: Combining ultrastructure expansion microscopy with immunofluorescence and Oligopaint DNA FISH. [PDF]

Chromosome Res
Raab LM, Hockens CB, Lee LS, Runyan RK, Burns EE, Rusan NM, Rosin LF.   +6 more
europepmc   +1 more source