Results 201 to 210 of about 134,839 (260)

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Haemanthidine-Containing Alkaloid Fraction from Crinum scabrum as a Natural Therapeutics for Chagas Disease

ACS Omega
Jennifer Blandón Pardo, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Mirian Claudia de Souza Pereira, Natália Ferreira de Sousa, Luciana Scotti, Marcus Tullius Scotti, Warley de Souza Borges   +7 more
doaj   +1 more source

Structural adaptations of aboveground vegetative organs to cangas: A case study with the Amazonian species Carajasia cangae R.M.Salas, E.L.Cabral & Dessein (Rubiaceae), which grows on ferruginous outcrops. [PDF]

PLoS One
Silva KR, Boanares D, Rossi ML, Filgueira JPPS, Martinelli AP, Carvalho C, Caldeira CF, Watanabe MTC.   +7 more
europepmc   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson's and dementia with Lewy bodies. [PDF]

Acta Neuropathol
Shafiei N, Proniakova D, Simjanoska M, Sjødal AMR, Stähli D, van den Heuvel L, Di Fabrizio M, Aaron E, Kasas S, Krause MS, Wittwer M, Radecke J, Stahlberg H, van de Berg WDJ, Lewis AJ.   +14 more
europepmc   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Targeting the Hippo/YAP-TAZ pathway increases X-ray sensitivity in chondrosarcoma spheroids and is associated with autophagic disruption. [PDF]

J Bone Oncol
Lohberger B, Glänzer D, Kaltenegger H, Kolb D.   +3 more
europepmc   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

Multi-omics analysis reveals gut microbiota-host metabolism-shell gland axis underlying eggshell deterioration in aged laying hens. [PDF]

Poult Sci
Zhao X, Liu Q, Tian Y, Cui X, Du Y, Yue Y, Lei X, Chen Z, Zhang F.   +8 more
europepmc   +1 more source

Subcellular Localization of Iron in Rhizophora mangle Leaves Revealed by Integrated Perls Reaction, TEM, STEM‐HAADF, and EDS Analyses

Microscopy Research and Technique, EarlyView.
Perls–TEM–STEM‐HAADF–EDS enables high‐resolution localization and elemental characterization of Fe‐containing deposits in Rhizophora mangle leaf cells. ABSTRACT Mangrove ecosystems are frequently exposed to high concentrations of iron (Fe) in sediments, resulting in Fe accumulation in plant tissues. Although Fe is an essential micronutrient involved in
Silvia Rodrigues Machado, Hiulana Pereira Arrivabene, Camilla Rozindo Dias Milanez, Margarida Juri Saeki, Yve Canaveze   +4 more
wiley   +1 more source