Results 41 to 50 of about 134,839 (260)

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Relation of mitochondrial phospholipase A activity to mitochondrial swelling

Journal of Lipid Research, 1969
Assays of mitochondrial phospholipase A activity and mitochondrial swelling demonstrated that the phospholipase A activity is related to the swelling under the experimental conditions used.
Moseley Waite, L.L.M. van Deenen, T.J.C. Ruigrok, P.F. Elbers   +3 more
doaj   +1 more source

Three in one: evolution of viviparity, coenocytic placenta and polyembryony in cyclostome bryozoans

BMC Ecology and Evolution, 2021
Background Placentation has evolved multiple times among both chordates and invertebrates. Although they are structurally less complex, invertebrate placentae are much more diverse in their origin, development and position.
U. A. Nekliudova, T. F. Schwaha, O. N. Kotenko, D. Gruber, N. Cyran, A. N. Ostrovsky   +5 more
doaj   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source

Hyperactivity is linked to elevated cortisol levels: comprehensive behavioral analysis in the prenatal valproic acid-induced marmoset model of autism

Translational Psychiatry
Hyperactivity is frequently observed in individuals with autism spectrum disorder (ASD) and significantly affects various aspects of life. This underscores the critical need for effective intervention methods tailored to the needs of individuals with ASD.
Madoka Nakamura, Toru Nakamura, Akiko Nakagami, Keiko Nakagaki, Nobuyuki Kawai, Noritaka Ichinohe   +5 more
doaj   +1 more source

Selection and isolation of bacterium with probiotic potential from the Amazon ornamental fish Hypancistrus sp. (Siluriformes, Loricariidae)

Boletim do Instituto de Pesca, 2023
The aim of this study was to select autochthonous bacteria with probiotic potential from the gastrointestinal tract of King Tiger Pleco (Hypancistrus sp.) for future applications in captive production.
Ryuller Gama Abreu Reis, Higo Andrade Abe, Natalino da Costa Sousa, Rossineide Martins da Rocha   +3 more
doaj  

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The Ultrastructure of the Developing Urodele Notochord

, 1962
THE ULTRASTRUCTURE OF THE DEVELOPING URODELE NOTOCHORD The Ultrastructure of the Developing Urodele Notochord (156) (-
Waddington, Conrad Hal Margaret M. Perry
core   +1 more source

Impact of 2D versus 3D fibroblast models on Leishmania species invasion in vitro: Rab5 dynamics and actin activity in initial infection

Frontiers in Cellular and Infection Microbiology
BackgroundThe protozoan Leishmania, in addition to infecting phagocytic cells such as macrophages, can also invade non-professional phagocytic cells like fibroblasts, a process previously described in 2D models.
Rebecca Thereza Silva Santa Brígida, Rebecca Thereza Silva Santa Brígida, Adeniele Lopes da Cruz Carneiro, Adeniele Lopes da Cruz Carneiro, Felipe Tuji de Castro Franco, Brenda Furtado Costa, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +7 more
doaj   +1 more source