Results 211 to 220 of about 221,628 (302)

Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines

Experimental Physiology, EarlyView.
Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu, Wei‐Chen Yeh, Yi‐Wei Fang, Ko‐Hsuan Lo, Lei‐Ni Liang, Xu‐Chen Liu, Chia‐Chi Tsai, Chih‐Cheng Cheng, Meng‐Chieh Lin, Hsin‐Hsien Yu, Bor‐Chyuan Su   +10 more
wiley   +1 more source

Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages. [PDF]

J Comp Neurol
Mellott JG, Dellaria LM, Guy M, Hergenrother SR, Tokar NJ, Smallridge DZ, Terzic M, Young JW, Dengler-Crish CM.   +8 more
europepmc   +1 more source

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Modulating alfalfa growth: impacts of plant growth regulators on physiology, architecture, and seed yield. [PDF]

BMC Plant Biol
Wang X, Liu Y, Sui X, Li K, Yimingniyazi A, Jin L, Lang M.   +6 more
europepmc   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Three dimensional visualization of subcellular and suborganellar structures in near-native plant cells by synchrotron soft X-ray tomography. [PDF]

Front Plant Sci
Hua MD, Lin YH, Hsieh CC, Chen CL, Lin ZJ.   +4 more
europepmc   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Haemanthidine-Containing Alkaloid Fraction from Crinum scabrum as a Natural Therapeutics for Chagas Disease

ACS Omega
Jennifer Blandón Pardo, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Mirian Claudia de Souza Pereira, Natália Ferreira de Sousa, Luciana Scotti, Marcus Tullius Scotti, Warley de Souza Borges   +7 more
doaj   +1 more source

Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells: differences between stem-like and differentiated cancer cells in response to chemotherapy. [PDF]

Radiol Oncol
Bogataj U, Novak M, Galun SK, Tacer KF, Vittori M, Noorden CJFV, Breznik B.   +6 more
europepmc   +1 more source

Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease

The Journal of Physiology, EarlyView.
Abstract figure legend This review utilized animal models of complicated human pregnancies that result in reduced fetal nutrient or oxygen delivery, or combined nutrient and oxygen delivery, to elucidate their independent and/or synergistic contributions to the development of high‐risk cardiac phenotypes.
Melanie R. Bertossa, Jack R. T. Darby, Ashley S. Meakin, Mitchell C. Lock, Steven K. S. Cho, Christopher K. Macgowan, Mike. Seed, Michael D. Wiese, Janna L. Morrison   +8 more
wiley   +1 more source