Results 201 to 210 of about 135,815 (306)

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

open access: yesiNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang   +3 more
wiley   +1 more source

Changes in Connexin-43 Expression and Neuropil Ultrastructure in the Cerebral Cortex of Bats During the Sleep-Wake Cycle. [PDF]

open access: yesInt J Mol Sci
Rodkin S   +6 more
europepmc   +1 more source

Mechanical memory in aging: From adaptive sensing to pathological entrenchment

open access: yesInterdisciplinary Medicine, EarlyView.
Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang   +7 more
wiley   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati   +6 more
wiley   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo   +10 more
wiley   +1 more source

Structural Remodeling of Mitochondrial Membranes in Cancerous Colon Cells: Insights from Neutron Scattering and Lipidomics. [PDF]

open access: yesACS Bio Med Chem Au
Castillo SR   +12 more
europepmc   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik   +3 more
wiley   +1 more source

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