Results 81 to 90 of about 225,866 (281)

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Mistletoe‐ and Mussel‐Inspired Fabrication of Hierarchically Structured Protein‐Cellulose Scaffolds From Biomolecular Condensates

Advanced Materials, EarlyView.
Merging materials processing tricks inspired by mussel and mistletoe fiber fabrication, solutions of cationic mussel byssus proteins were mixed with modified anionic nanocrystalline cellulose, producing distinctive core‐shell condensates. Simple processing of condensate suspensions using freeze‐drying produced hierarchically structured porous protein ...
Hamideh R. Alanagh, Seyed Mohammad Amin Ojagh, Arman Jafari, Xinyu Zhan, Tara Sprules, Alexandre Poulhazan, Houman Savoji, Adam G. Hendricks, Theo G.M. van de Ven, Matthew J. Harrington   +9 more
wiley   +1 more source

Scratching the Surface: Bacterial Cell Envelopes at the Nanoscale

mBio, 2020
The bacterial cell envelope is essential for viability, the environmental gatekeeper and first line of defense against external stresses. For most bacteria, the envelope biosynthesis is also the site of action of some of the most important groups of ...
Albertus Viljoen, Simon J. Foster, Georg E. Fantner, Jamie K. Hobbs, Yves F. Dufrêne   +4 more
doaj   +1 more source

Correlative Super‐Resolution Imaging of Cellular Nanopores Facilitated by Transparent Polymer Waveguide Chips

Advanced Optical Materials, Volume 13, Issue 8, March 13, 2025.
Correlative super‐resolution optical imaging of the ultrastructure of rat liver sinusoidal endothelial cells (LSECs) across a large field of view (FOV) with 3D structured illumination microscopy (3D‐SIM) and single‐molecule localization microscopy (SMLM), facilitated by a transparent polymer photonic waveguide chip, is presented.
Surjendu Bikash Dutta, Jasmin Celine Schürstedt‐Seher, Anders Kokkvoll Engdahl, Wolfgang Hübner, Stefan Belle, Karolina Szafranska, Peter McCourt, Ralf Hellmann, Mark Schüttpelz, Thomas Huser   +9 more
wiley   +1 more source

Genetic variation in eggshell crystal size and orientation is large and these traits are correlated with shell thickness and are associated with eggshell matrix protein markers [PDF]

, 2012
The size and orientation of calcium carbonate crystals influence the structure and strength of the eggshells of chickens. In this study, estimates of heritability were found to be high (0.6) for crystal size and moderate (0.3) for crystal orientation ...
Ahmed, Arias, Barrett, Chien, Dunn, Dunn, Fernandez, Francesch, Freeman, Gautron, Hall, Hamilton, Hernandez-Hernandez, Hincke, Hincke, Mann, Nys, Nys, Panheleux, Patterson, Preisinger, Rodríguez-Navarro, Rodríguez-Navarro, Rodríguez-Navarro, Rodríguez-Navarro, Rodríguez-Navarro, Tullett, Tyler, Vantoledo   +28 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Applying vinpocetine to reverse synaptic ultrastructure by regulating BDNF-related PSD-95 in alleviating schizophrenia-like deficits in rat

Comprehensive Psychiatry, 2019
Background: Schizophrenia is a mental disorder characterized by hyperlocomotion, cognitive symptoms, and social withdrawal. Brain-derived neurotrophic factor (BDNF) and postsynaptic density (PSD)-95 are related to schizophrenia-like deficits via ...
Yue Xu, Chao Deng, Yongqiang Zheng, Nannuan Liu, Beibei Fu   +4 more
doaj   +1 more source

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. [PDF]

, 2019
Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein
Cheng, Hongqiang, Ghosh, Sourav, Hejran, Helen, Klezovitch, Olga, Lee, Su-Yee, Mao, Ye, Mu, Yongxin, Qin, Huaping, Scott, John, Thakar, Sonal, Vasioukhin, Valeri, Yu, Ting, Zou, Yimin   +12 more
core   +1 more source

Assessment of crystallographic influence on material properties of calcite brachiopods [PDF]

, 2008
Calcium carbonate biominerals are frequently analysed in materials science due to their abundance, diversity and unique material properties. Aragonite nacre is intensively studied, but less information is available about the material properties of ...
A. Pérez-Huerta, Lowenstam, M. Cusack, W. Zhu   +3 more
core   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source