Results 31 to 40 of about 1,527,904 (296)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

ISSIS: the imaging and slitless spectroscopy instrument for surveys in the World Space Observatory-Ultraviolet telescope

, 2012
Conference on Space Telescopes and Instrumentation 2012 - Ultraviolet to Gamma Ray, Amsterdam, NETHERLANDS, JUL 01-06, 2012ISSIS is the Imaging and Slitless Spectroscopy Instrument for the World Space Observatory - Ultraviolet (WSO-UV), a 170 cm space ...
Paola Sestito, Sestito, Paola, Jose Quintana, Marcos Ubierna, Sánchez, Néstor, Teresa Gómez, Maite, Nestor Sanchez, Juan Seijas, Rodríguez, Pablo, Quintana, Jose, López Martínez, Fátima, Ubierna, Marcos, Seijas, Juan, Ana I. Gomez de Castro, Jacinto Muñoz, Maite Teresa Gomez, Gómez De Castro, Ana Inés, Muñoz, Jacinto, Fatima Lopez-Martinez, Pablo Rodriguez   +19 more
core   +1 more source

Angle- and spin-resolved photoelectron spectroscopy of the Hg 5d10 subshell [PDF]

, 1982
Schönhense G, Schäfers F, Heinzmann U, Kessler J. Angle- and spin-resolved photoelectron spectroscopy of the Hg 5d10 subshell. Zeitschrift für Physik A: Hadrons and Nuclei.
Kessler, J., Schäfers, F., Heinzmann, Ulrich, Schönhense, G.   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Garlic Origin Traceability and Identification Based on Fusion of Multi-Source Heterogeneous Spectral Information

Foods
The chemical composition and nutritional content of garlic are greatly impacted by its production location, leading to distinct flavor profiles and functional properties among garlic varieties from diverse origins.
Hao Han, Ruyi Sha, Jing Dai, Zhenzhen Wang, Jianwei Mao, Min Cai   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The LOUVRE Laboratory: State-of-the-Art Ultrafast Ultraviolet Spectroscopies for Molecular and Materials Science

CHIMIA, 2017
We describe the facilities for ultraviolet studies in the femtosecond to nanosecond time domain. These facilities consist of: i) a set-up for deep-ultraviolet spectroscopy in the 260–380 nm range in both pump and probe pulses for transient ...
Malte Oppermann, Frank van Mourik, Thomas Rossi, Tania Palmieri, Benjamin Bauer, Lars Mewes, Edoardo Baldini, Aurelio Oriana, Natalia S. Nagornova, Majed Chergui   +9 more
doaj   +1 more source