Umbelliferone aminoalkyl derivatives as inhibitors of human oxidosqualene-lanosterol cyclase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2009 Human and murine lanosterol synthases (EC 5.4.99.7) were studied as targets of a series of umbelliferone aminoalkyl derivatives previously tested as inhibitors of oxidosqualene cyclases from other eukaryotes. Tests were carried out on cell cultures of human keratinocytes and mouse 3T3 fibroblasts incubated with radiolabeled acetate, and on homogenates ...
OLIARO BOSSO, Simonetta +6 more
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Umbelliferone and Esculetin: Inhibitors or Substrates for Polyphenol Oxidases?
Biological and Pharmaceutical Bulletin, 2008 Recently, an interesting debate arose about the nature (substrate versus inhibitor) of esculetin, a coumarin derivative, for mushroom polyphenol oxidase (PPO). The present study examined the behavior of PPOs preparations from fungal and plant origin towards esculetin as a substrate. Both enzymes were able to oxidize esculetin though at a slow rate.
Sollai, F +4 more
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1H-NMR dataset for hydroxycoumarins –Aesculetin, 4-Methylumbelliferone, and umbelliferone
Data in Brief, 2016 Herein, the integrated raw data regarding the (1)H-NMR, experiments of Aesculetin, 4-Methylumbelliferone, and umbelliferone, in Acetone-d(6) at 25 °C, are presented for further analysis and comparison purposes, for whom may be interested.
Rui Galhano dos Santos +2 more
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Chemical tools to probe carbohydrate recognition and glycoconjugate biosynthesis [PDF]
, 2015 In eukaryotes the assembly of complex glycoconjugate structures takes place in the endoplasmic reticulum (ER) and Golgi apparatus, where a number of specific membrane-bound glycosyltransferases transfer sugar moiety from soluble or lipid linked activated
Ivanova, Irina
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Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery [PDF]
, 2016 2014 - 2015The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, influencing ...
Feoli, Alessandra
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Grundlegende Untersuchungen zur Entwicklung Bioorthogonaler Reaktionssysteme auf Basis von Olefinmetathesereaktionen [PDF]
Carrying out artificial chemical reactions in living cells is one of the greatest challenges in modern chemistry. To date, there are only a few reactions that are able to fulfil the strict constraints of a bioorthogonal reaction.
Benkert, Tobias
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Zur Kenntniss des Umbelliferons [PDF]
Berichte der deutschen chemischen Gesellschaft, 1886 W. Will, P. Beck
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Caractérisation fonctionnelle des NTPDASE1, NTPDASE2, NTPDASE8 et de l'ecto-5'-nucléotidase hépatiques [PDF]
, 2018 Le foie possède une forte activité d'hydrolyse de l'ATP extracellulaire associée aux canalicules biliaires qui a longtemps été utilisée comme marqueur de cette structure.
Fausther, Michel
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Development of microbiological molecular diagnostic techniques for the rapid screening and identification of selected human bacterial pathogens and indicators [PDF]
, 2009 This work, we believe, is a significant contribution to the development of molecular methods for the rapid detection of microorganism interacting with humans.
Anglès d Auriac, Marc B.
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Preparation of Silica Nanoparticles for Biomedical Applications: Bacterial Detection, Oral Drug Delivery and Colloidal Stability [PDF]
, 2017 The new branch of medicine, nanomedicine, implies the use of engineered devices and nanostructures in order to accelerate the knowledge of biomolecular-biological processes, to improve the efficiency of disease therapeutics and to develop novel ...
Giovannini, Giorgia
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