Results 241 to 250 of about 598,980 (267)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

Exploring the critical therapeutic window: Dose-frequency optimization of human umbilical cord mesenchymal stem cells for preclinical asthma treatment. [PDF]

World J Stem Cells
Chen QH, Zheng JY, Zhu YQ, Zhang JY, Lin CY, Zhuang XE, Cheng J, Huang XY.   +7 more
europepmc   +1 more source

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

Annals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije, Sara T. De Palma, Josine E. G. Vaes, Katiuscia Dallaglio, Giorgia Volpi, Diego Ardigò, Sabine van Rijt, Frank van Bel, Manon J. N. L. Benders, Cora H. A. Nijboer   +9 more
wiley   +1 more source

Umbilical Aesthetics in Kenya: A Survey of Shape, Position, and Gender Preferences. [PDF]

Plast Reconstr Surg Glob Open
Fofung SK, Wabwire B, Wanjeri JK.
europepmc   +1 more source

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source

Utilization of enhanced-view total extraperitoneal technique for combined epigastric hernia and umbilical hernia repair: a case report. [PDF]

J Minim Invasive Surg
Kimura K, Yamabuki T, Yamamoto H, Sato S, Takada M, Hirano S.   +5 more
europepmc   +1 more source

Telomerase Activity in Human Umbilical Cord Cell Populations Containing Hematopoietic Stem Cells

, 2002
Vidya Murthy
openalex   +1 more source

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, EarlyView.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source

MR Imaging of Umbilical Cord Variations, Abnormalities, and Associated Placental Findings. [PDF]

Magn Reson Med Sci
Kageyama S, Sato T, Iwama N, Hamada H, Saito M, Takase K.   +5 more
europepmc   +1 more source

Multifunctional Hydrogel‐Based wound Dressings for Scar‐Free Healing: Design Principles, Therapeutic Mechanisms, and Clinical Translation Challenges

Advanced NanoBiomed Research, EarlyView.
This review integrates scar biology with hydrogel‐based therapeutic strategies, offering a phase‐specific framework to correlate hydrogel functions with scar‐influencing events. It highlights innovations such as stimuli‐responsive hydrogels, nanocomposite systems, and 3D‐printed scaffolds, while addressing clinical translation challenges like ...
Haonan Chai, Zhenxing Wang, Jingyi Ju, Jiaming Sun   +3 more
wiley   +1 more source