Results 161 to 170 of about 551,971 (288)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Utility of Admission and Intrapartum Cardiotocography for Predicting Umbilical Artery pH Status at Birth: A Retrospective Cohort Study in Iran. [PDF]

open access: yesHealth Sci Rep
Golshahi F   +10 more
europepmc   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

open access: yesSmart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

open access: yesSusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang   +12 more
wiley   +1 more source

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

open access: yesVIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi   +5 more
wiley   +1 more source

The Performance of Selective Screening Ultrasound to Detect the Small‐for‐Gestational‐Age Foetus: A Prospective Cohort Study Nested Within the DESiGN Randomised Control Trial

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Evidence on the performance of foetal growth ultrasound parameters to detect the Small‐for‐Gestational‐Age (SGA) foetus for a selective cohort is limited. We report the performance of estimated foetal weight under the 10th percentile (EFW < 10th) at the last selective screening ultrasound to detect SGA based on gestational age of ...
Charles Arcus   +17 more
wiley   +1 more source

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