Results 41 to 50 of about 251,681 (200)

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

TIPIN Couples Epigenetic Rewiring to EGFR Stabilization and Lenvatinib Resistance in Liver Cancer

Advanced Science, EarlyView.
DNA hypomethylation elevates TIPIN expression in liver cancer. TIPIN competes with E3 ligase c‐Cbl for the EGFR intracellular domain, inhibiting EGFR ubiquitination and lysosomal degradation to sustain oncogenic EGFR‐ ERK signaling. High TIPIN confers lenvatinib resistance, while TIPIN depletion restores drug sensitivity in liver cancer. ABSTRACT Aims:
Xing Jia, Shiyu Zhang, Yangbo Tang, Shinuo Chen, Xingxin Zhu, Junran Chen, Suchen Bian, Lei Zheng, Chi Zhang, Haojing Ma, Wengfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Qinglin Li, Penghong Song   +15 more
wiley   +1 more source

Isogeometric contact analysis in subsea umbilical and power cables

Marine Structures
Subsea umbilical and power cables contain a large number of contact interfaces between different geometries and materials. These complex interactions rise significant challenges for accurately considering contact surface properties by using traditional analytical solutions or finite element methods.
Tianjiao Dai, Shuo Yang, Xing Jin, Svein Sævik, Jiaxuan Zhang, Jun Wu, Naiquan Ye   +6 more
openaire   +3 more sources

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Endoscopically Assisted Periacetabular Osteotomy for Treatment of Hip Dysplasia: The Orthopaedic Total Extraperitoneal Approach

Arthroscopy Techniques, EarlyView.
Abstract The orthopaedic total extraperitoneal (O‐TEP) approach is an endoscopic technique that has recently emerged as an option, particularly for the surgical management of pelvic and acetabular fractures. Unlike conventional orthopaedic endoscopic procedures, O‐TEP was developed by adapting the laparoscopic totally extraperitoneal approach, commonly
Vedat Öztürk, Malik Çelik, Salih Çağdaşer, Önder Murat Hürmeydan, Furkan Çağlayan Aslantaş, Cemal Kural, Mustafa Gökhan Bilgili   +6 more
wiley   +1 more source

Draft report Hawaii Deep Water Cable Program (HDWCP) : cable repair rationale [PDF]

, 1986
The Hawaii Deep Water Cable (HDWC) program has a major objective of determining the technical feasibility of deploying and operating, over a service life of thirty years, a submarine power transmission cable between Kohala on the island of Hawaii and the
Hawaiian Dredging and Construction Company, Pirelli Cable Corporation, Makai Ocean Engineering   +2 more
core   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

A Study on the Inter-Medium Dynamic Response of a Deep-Sea Retrievable Umbilical–Payload System Under Wave–Ship Interaction

Applied Sciences
This study examines the strongly nonlinear cross-media dynamics of a deep-sea umbilical cable–payload system during free-surface crossing under different sea states and lifting speeds.
Chuanyilang Zhu, Shengyi Yang, Yangrui Cheng, Jun Li, Jianeng Bian, Xin Huang, Xiang Zhu   +6 more
doaj   +1 more source

Equipo para la verificación de conexiones soldadas de tuberías recubiertas internamente

AiBi Revista de Investigación, Administración e Ingeniería, 2020
El presente paper describe el diseño y la construcción de un equipo que permite la verificación de conexiones soldadas de tuberías recubiertas internamente, utilizadas en el transporte de fluidos del sector petrolero, permitiendo caracterizar las ...
William Aperador-Chaparro, Gabriel Humberto Castiblanco   +1 more
doaj   +1 more source