Results 91 to 100 of about 5,050,821 (258)

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis‐Related Biomarkers

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background The efficacy of neoadjuvant chemotherapy (NAC) combined with surgery and postoperative adjuvant chemotherapy in improving the prognosis of locally advanced gastric cancer (LAGC) has been confirmed. Nevertheless, there is still no effective tool to predict the response to NAC in gastric cancer patients.
Minxuan Shen, Qinbo Cai, Rongchang Wang, Feiran Zhang, Huanjie Chen, Xiaoqun Wang, Rongman Xie, Jie Zhang, Baoyi Liu, Yulong He, Xun Hou, Dongjie Yang   +11 more
wiley   +1 more source

A Farm‐To‐Fork Framework to Assess the Scope and Limitations of Agricultural Data Structures

Modern Agriculture, Volume 3, Issue 2, December 2025.
The diagram illustrates the agricultural data structures evaluation process using AgrIMAF. The data structures were gathered from the literature and ranged from data models and conceptual frameworks to file‐based systems and databases. They are then systematically analysed through the AgrIMAF structure, which consists of three layers, that is, the ...
Cheikh M. M. Thiaw, Louis R. E. Asie, Herlest B. Lovince, Alain N. Rousseau, Paul Celicourt   +4 more
wiley   +1 more source

Modeling and Analysis of a LOX/Ethanol Liquid Rocket Engine

Journal of Aerospace Technology and Management, 2018
This work studies the performance and dry mass of the under development LOX/Ethanol L75 liquid rocket engine. To this end, an object-oriented program written in C++ was developed.
Fábio Antônio da Silva Mota, José Nivaldo Hinckel, Evandro Marconi Rocco, Hanfried Schlingloff   +3 more
doaj  

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, Volume 599, Issue 21, Page 3113-3123, November 2025.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

A UML tool for an automatic generation of simulation programs

Workshop on Software and Performance, 2000
L. Arief, N. Speirs
semanticscholar   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, Volume 599, Issue 21, Page 3047-3065, November 2025.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, Volume 19, Issue 11, Page 3409-3426, November 2025.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

An aspect-oriented UML tool for software development with early aspects

Eä, 2006
Yang Wang, Santokh Singh, J. Hosking, J. Grundy   +3 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, Volume 15, Issue 11, Page 1771-1788, November 2025.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source