Results 101 to 110 of about 5,050,821 (258)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, Volume 15, Issue 11, Page 1886-1899, November 2025.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Students' Application of Abstract and Systems Thinking Skills for Modeling Software Systems

open access: yesComputer Applications in Engineering Education, Volume 33, Issue 6, November 2025.
ABSTRACT Software modeling is an essential practice in software engineering, requiring the application of both abstract thinking and systems thinking. Despite its importance, there is limited empirical research on how these cognitive skills are enacted during the modeling process.
Paul J. Thomas, Alejandra J. Magana
wiley   +1 more source

Meta‐Metamodelling of Engineering Systems by Help of Abstract Mathematics

open access: yesMathematical Methods in the Applied Sciences, Volume 48, Issue 16, Page 14815-14827, 15 November 2025.
ABSTRACT The growing trend of automation in engineering significantly increases the complexity of engineering systems and necessitates a deeper understanding of the coupling of physical and cyber components interacting within the systems. A typical example of such a highly coupled system is an autonomous construction site, where robotic systems aim to ...
Daniel Luckey, Dmitrii Legatiuk
wiley   +1 more source

Carbon Nanotube Hydrogels Reveal Threshold‐Dependent Regulation of Neuroblastoma Cell Growth and Maturation by Mechanical and Chemical Factors

open access: yesSmall Science, Volume 5, Issue 11, November 2025.
Poly(vinyl alcohol)/carbon nanotube (PVA/CNT) hydrogels with unprecedented CNT loading (75% w/w) were engineered as 3D scaffolds for nerve regeneration. By tuning Young's modulus (YM), CNT concentration, and pore size, distinct thresholds controlling cell coverage were identified. Optimized scaffolds achieved > 70% coverage and upregulated β‐3‐tubulin (
Bahaa Daou   +3 more
wiley   +1 more source

Generating Logical Architectures from SysML Behavior Models

open access: yesSystems Engineering, Volume 28, Issue 6, Page 762-778, November 2025.
ABSTRACT Modeling solution‐neutral operating principles of system features as SysML behavior models enable systems engineers to specify reusable product features for a variety of similar products and to specify and document a product's functionality in an easy‐to‐understand manner.
Christian Granrath   +4 more
wiley   +1 more source

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