Results 111 to 120 of about 5,050,821 (258)

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades   +4 more
wiley   +1 more source

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 22, Page 5517-5535, November 2025.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan   +6 more
wiley   +1 more source

JGOOSE: A REQUIREMENTS ENGINEERING TOOL TO INTEGRATE I* ORGANIZATIONAL MODELING WITH USE CASES IN UML [PDF]

open access: diamond, 2009
André Vicente   +4 more
openalex   +1 more source

Human tissue kallikrein 14 induces the expression of IL‐6, IL‐8, and CXCL1 in skin fibroblasts through protease‐activated receptor 1 signaling

open access: yesThe FEBS Journal, Volume 292, Issue 21, Page 5659-5675, November 2025.
Human tissue kallikrein 14 (KLK14), a skin protease, may mediate paracrine signaling in wound healing. KLK14 released by epithelial cells activates fibroblasts via PAR‐1 activation, inducing IL‐6, IL‐8, and CXCL1 expression. These cytokines in turn promote keratinocyte proliferation and migration, resulting in wound closure.
Laura Sasiadek   +16 more
wiley   +1 more source

Perancangan Sistem Informasi Penjualan Online Barang Graffiti Pada Toko Outline Graff Store Semarang

open access: yesJOINS (Journal of Information System), 2017
Perkembangan  teknologi informasi  yang pesat sangat berpengaruh dalam dunia bisnis. Pada era globalisasi masyarakat menuntut penyajian informasi yang disajikan  dapat berjalan dengan cepat , akurat dan mudah digunakan.
Renaldi Aulia Sani, Lalang Erawan
doaj  

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