Results 41 to 50 of about 5,155,579 (288)
Overview of Slicing and Feedback Techniques for Efficient Verification of UML/OCL Class Diagrams
IEEE Access, 2018 Model-driven engineering is a methodology for software development that focuses on the use of models in the software development process. These models can be transformed into code, saving developers both time and effort.
Asadullah Shaikh, Uffe Kock Wiil
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
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Pattern-based model refactoring for the introduction association relationship
Journal of King Saud University: Computer and Information Sciences, 2015 Refactoring is an important software development process involving the restructuring of a model to improve its internal qualities without changing its external behavior.
Boulbaba Ben Ammar, Mohamed Tahar Bhiri
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Applied Sciences, 2022 The exchange of information among information technology (IT) systems is inevitable. Service fulfillment often involves sending and receiving messages. The article presents a set of messaging patterns for service-oriented architecture, microservices, and
Tomasz Górski
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Are the UML modelling tools powerful enough for practitioners? A literature review
IET Software, 2019 Unified Modelling Language (UML) is essentially a de-facto standard for software modeling and supported with many modeling tools. In this study, 58 UML tools have been analysed for modelling viewpoints, analysis, transformation & export, collaboration ...
Mert Ozkaya
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
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Qualitative Requirements Elicitation of Student Requirements for Tool-supported Teaching of UML Diagrams [PDF]
, 2023 Florian Huber +3 more
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
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