Results 41 to 50 of about 5,050,821 (258)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A UML profile for documenting the component-and-connector view of software architectures

Journal of Computer Science and Technology, 2008
In this paper, we present a UML profile and a group of UML patterns for documenting the component-andconnector views of software architectures [8]. They facilitate the creation of the component and connector viewtype in any UML 2.0 tool with a compliance
Valerio Adrián Anacleto
doaj  

UML Profile for Messaging Patterns in Service-Oriented Architecture, Microservices, and Internet of Things

Applied Sciences, 2022
The exchange of information among information technology (IT) systems is inevitable. Service fulfillment often involves sending and receiving messages. The article presents a set of messaging patterns for service-oriented architecture, microservices, and
Tomasz Górski
doaj   +1 more source

An integration of uml use case diagram and activity diagram with Z language for formalization of library management system

International Journal of Electrical and Computer Engineering (IJECE), 2019
Unified Modeling Language (UML) is the effective standard for modeling object-oriented software systems. However, the ambiguity of semantics and the absence of consistency among UML diagrams lead to lack of precisely defining the requirements of a system.
Zainab Hassan Muhamad, Dhafer Abdulameer Abdulmonim, Bashar Alathari   +2 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Daugiaplatformės programinės ir sisteminės įrangos kūrimo priemonės koncepcija

Informacijos Mokslai, 2009
Straipsnyje pateikta daugiaplatformės programinės įrangos kūrimo ir integravimo į įterptinės sistemos sisteminę įrangą (ang. fi rmware), kūrimo priemonės koncepcija, kurios veikimo pagrindą sudaro generuojančios sistemos.
Mindaugas Vidmantas, Egidijus Kazanavičius   +1 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Reengineering Fuzzy Spatiotemporal UML Data Model Into Fuzzy Spatiotemporal XML Model

IEEE Access, 2017
Spatiotemporal information and application have received considerable attention. Spatiotemporal information is often imprecise or uncertain; therefore, the establishment of a reasonable and effective fuzzy spatiotemporal data model is vital.
Xu Chen, Li Yan, Weijun Li, Zongmin Ma
doaj   +1 more source

Applying Model-Driven Engineering to Distributed Ledger Deployment

IEEE Access, 2020
Distributed Ledger Technology (DLT) enables data storage in a decentralized manner among collaborating parties. The software architecture of such solutions encompasses models placed in the relevant architectural views.
Tomasz Gorski, Jakub Bednarski
doaj   +1 more source