Results 61 to 70 of about 5,155,579 (288)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
ANALYSING UML-BASED SOFTWARE MODELLING LANGUAGES
Havacılık ve Uzay Teknolojileri Dergisi, 2018 UML is considered as the top popular software modelling language among practitioners. Expectedly, UML has been extended by many other languages, which tailor UML for particular domains (e.g., distributed systems, mobile systems, and embedded systems). In
Mert Ozkaya
doaj
Transforming Sketches of UML Use Case Diagrams to Models
IEEE AccessConsidering that use case specification often plays the most important role in requirements engineering, transitioning from a design on paper to an editable, standard-compliant model is a fitting candidate for automation.
Mantas Razinskas +4 more
doaj +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
OBJECT ORIENTED MODELLING, A MODELLING METHOD OF AN ECONOMIC ORGANIZATION ACTIVITY [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2014 Now, most economic organizations use different information systems types in order to facilitate their activity. There are different methodologies, methods and techniques that can be used to design information systems.
TĂNĂSESCU ANA
doaj
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Code Generation from UML Model: State of the Art and Practical Implications
Applied Computer Systems, 2013 The paper draws attention to the problem of code generation under advanced software development. In their previous publications the authors already discussed several issues associated with the inconsistency between the generated software components and ...
Bajovs Andrejs +2 more
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Modeling and Solving a Latin American University Course Timetabling Problem Instance
Mathematics, 2020 Timetabling problem is a complex task that is performed by a number of institutions worldwide, which has been usually addressed as an optimization problem where every approach considers the particular constraints of each institution under consideration ...
Oscar Chávez-Bosquez +3 more
doaj +1 more source