Results 131 to 140 of about 14,762,295 (297)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
Global Enhancement of Vehicle Safety – the Urgency of Now
Journal of Road Safety, 2016 The United Nations (UN) Global Goals for Sustainable Development have set the ambitious goal of reducing road fatalities and serious injuries by 50% by the end of the current UN Decade of Action for Road Safety (2011-2020).
David Ward, Jessica Truong
doaj
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Networked media and information ocean literacy: a transformative approach for UN ocean decade
npj Ocean SustainabilityThe United Nations’ Ocean Decade calls for co-designing transformative science, ocean networks, and learning strategies to address ocean health decline and deep-blue social divides in ocean governance.
Leopoldo Cavaleri Gerhardinger +8 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Journal of Road Safety, 2016 Delivery of road safety is an urgent global priority, as recognised by key events over recent years. The establishment of the United Nations (UN) Decade of Action for Road Safety and the subsequent development of the UN Global Plan for the Decade of ...
Soames Job, Chika Sakashita
doaj
The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing. [PDF]
Public Health Nutr, 2018 Monteiro CA +5 more
europepmc +1 more source