Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui +5 more
wiley +1 more source
Delivery of Electricity to Cluster-like Consumers [PDF]
Unbalanced power lines (whose conductors are not arranged in the vertices of equilateral triangle) without overhead grounding wire (OGW) besides Fortesque impedances Z0 and Z1=Z2 have mutual impedances Z01, Z10, Z02, Z20, Z12, Z21. At the end of the line,
Survilo, Josifs
core
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Numerical backup protection scheme based on alienation indices of voltage and current measurements practically applied to synchronous generators. [PDF]
Mahmoud RA, Salama MAE.
europepmc +1 more source
Redox signals and oxidative stress in the control of mitochondrial protein import
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg +3 more
wiley +1 more source
Digital protection scheme based on Durbin Watson and Pearson similarity indices for current signals practically applied to power transformers. [PDF]
Mahmoud RA.
europepmc +1 more source
Diethyl Aminoethyl Hexanoate Increase Relay Strip Intercropping Soybean Grain by Optimizing Photosynthesis Aera and Delaying Leaf Senescence. [PDF]
Luo K +10 more
europepmc +1 more source
ABSTRACT Background Speech sound disorder (SSD) is broadly defined as difficulty producing speech sounds in childhood. It can have a lasting impact on academic outcomes and well‐being, making effective early intervention vital. Speech and language therapists (SLTs) consider parental involvement—particularly supporting their child with home practice—as ...
Katherine Pritchard +3 more
wiley +1 more source
Chronic foot stress increases the vulnerability of adolescent mice to alcohol addiction‐related behaviours. Acute foot stress promotes the recovery of alcohol‐seeking behaviour in adolescent mice and increases orexin concentrations in the hippocampus, nucleus accumbens and prefrontal cortex.
Wenhao He +5 more
wiley +1 more source

