Results 81 to 90 of about 337,693 (183)

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, EarlyView.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

How Do Management Choices Impact the Performance of Cassava‐Legume Intercropping in Africa? A Meta‐Analysis

Journal of Sustainable Agriculture and Environment, Volume 5, Issue 2, June 2026.
ABSTRACT Intercropping can enable sustainable intensification. In Africa, smallholder farmers rely on Cassava (Manihot esculenta Crantz) as a staple food. Nevertheless, the performance of cassava intercropping emerges from management choices such as legume species selection, planting density, sowing time, and nitrogen (N) fertilisation as well as soil ...
Dorcas I. Aisien, Guillermo Hernandez‐Ramirez, Akim Omokanye   +2 more
wiley   +1 more source

When virtues are weaponized: Moral superiority aggravates outgroup dehumanization

Political Psychology, Volume 47, Issue 3, June 2026.
ABSTRACT Moral superiority has been suggested to exacerbate intergroup relations. However, empirical studies testing the negative intergroup outcomes arising from moral superiority are limited, and the underlying mechanisms remain to be explored. We aimed to fill this research gap by examining whether and how moral superiority increases outgroup ...
Zaixuan Zhang, Zhansheng Chen
wiley   +1 more source

Towards Geographies of Silence: Unspoken Boundaries

Transactions of the Institute of British Geographers, Volume 51, Issue 2, June 2026.
ABSTRACT Despite its social and spatial significance, silence remains an under‐explored and under‐theorised subject in geography. This paper addresses this lacuna by examining silence as a boundary‐making practice in geographically distant relationships.
Dora Sampaio
wiley   +1 more source

Diethyl Aminoethyl Hexanoate Increase Relay Strip Intercropping Soybean Grain by Optimizing Photosynthesis Aera and Delaying Leaf Senescence. [PDF]

Front Plant Sci, 2021
Luo K, Yuan X, Xie C, Liu S, Chen P, Du Q, Zheng B, Wu Y, Wang X, Yong T, Yang W.   +10 more
europepmc   +1 more source

Surgery in space: The ultimate frontier

Experimental Physiology, EarlyView.
Mohamad Bashir, Ali Murtada, Matti Jubouri, Adam Bashir, Ian Williams, Damian Bailey   +5 more
wiley   +1 more source