AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes
Advanced Intelligent Discovery, EarlyView.To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song +6 more
wiley +1 more source
Alignment of spatial transcriptomics slices across diseases, platforms and conditions. [PDF]
Genome MedWang Y, Liu Z, Zang Q, Ma X.
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.AI‐BioMech is a deep learning framework that predicts the mechanical behavior of biological cellular materials directly from 2D images. By replacing traditional finite element analysis with semantic segmentation, it identifies stress and strain distributions with 99% accuracy, offering a high‐speed, scalable alternative for analyzing complex, aperiodic
Haleema Sadia +2 more
wiley +1 more source
Estimating Trends With Differential Item Functioning: A Comparison of Five IRT-Based Approaches. [PDF]
Educ Psychol MeasEngels O, Lüdtke O, Robitzsch A.
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed +15 more
wiley +1 more source
The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells. [PDF]
Cell Commun SignalLarafa S +14 more
europepmc +1 more source
Robust Representation Learning for Clean Feature Discovery in Incomplete Multi‐View Clustering
Advanced Intelligent Systems, EarlyView.Robust feature discovery in incomplete multi‐view clustering is achieved by coupling RPCA‐based clean representation recovery with neural‐network‐assisted graph learning. The resulting RIMVC framework constructs cleaner and more discriminative graph‐structured representations from incomplete and noisy multi‐view data, improving clustering robustness ...
Ping Hu +4 more
wiley +1 more source
A High‐Voltage Membrane‐Free Li–Organic Hybrid Flow Battery Using Eutectic Lithium Chemistry
Angewandte Chemie, EarlyView.A high‐voltage (3.6 V) membrane‐free Li–organic hybrid flow battery is enabled by a deep‐eutectic lithium electrolyte composed of trifluoroacetamide (TFAD) and LiPF6, paired with a dichloromethane (DCM) catholyte containing phenothiazine (PTZ). The TFAD/LiPF6 eutectic provides fast Li+ transport and stable Li‐metal cycling, while the immiscible TFAD ...
Xiao Wang +7 more
wiley +2 more sources
Prevalence of traditional Chinese medicine body constitutions in a large community-based study in Hangzhou, China. [PDF]
Chin MedWu YH +11 more
europepmc +1 more source
Climate change and perennial crop production: Evidence of yield impact and adaptation in California
American Journal of Agricultural Economics, EarlyView.Abstract Perennial crops are economically important. They contribute to food security, providing essential nutrients that are often lacking in annual crops, and provide additional environmental benefits compared with annual crops. Despite their importance, empirical research on the impacts of climate change and adaptation on perennial crops remains ...
Yuanyuan Wen +2 more
wiley +1 more source