Results 71 to 80 of about 62,229 (344)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Voltage regulation considerations for the design of hybrid distribution transformers [PDF]

, 2014
The future substation depends on finding a way to mitigate the effects of the drawbacks of the conventional legacy by employing the efficiency of the solid state switches [1].
Alqarni, M, Darwish, M, Radi, MA
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Distorted Unbalanced Grid Voltage Modulated Direct Power Control for Three-Phase Grid-Connected Inverters

IEEE Open Journal of Power Electronics
In this paper, a linearized direct power control strategy for grid-connected inverters under distorted unbalanced grid voltage is proposed. The grid-connected inverters usually suffer from distorted unbalanced grid condition, which causes output active ...
Yi-Hung Liao, Meng-Hsuan Yu, Hao-Min Zhang   +2 more
doaj   +1 more source

Overview of three-phase inverter topologies for distributed generation purposes [PDF]

, 2010
The increasing presence of single-phase distributed generators and unbalanced loads in the electric power system may lead to unbalance of the three phase voltages, resulting in increased losses and heating.
De Kooning, Jeroen, Degroote, Lieven, Meersman, Bart, Renders, Bert, Vandevelde, Lieven, Vandoorn, Tine   +5 more
core   +1 more source

Alone Self-Excited Induction Generators [PDF]

, 2016
In recent years, some converter structures and analyzing methods for the voltage regulation of stand-alone self-excited induction generators (SEIGs) have been introduced.
Doser, TL, Kesler, S
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Variable-Angle Phase-Shifted PWM for Multilevel Three-Cell Cascaded H-bridge Converters [PDF]

, 2017
Multilevel cascaded H-bridge converters have become a mature technology for applications where high-power medium ac voltages are required. Normal operation of multilevel cascaded H-bridge converters assumes that all power cells have the same dc voltage ...
Freire Macías, Emilio, García Franquelo, Leopoldo, Kouro, Samir, León Galván, José Ignacio, Márquez Alcaide, Abraham, Portillo Guisado, Ramón Carlos, Vázquez Pérez, Sergio   +6 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source