Results 71 to 80 of about 2,384 (218)

Shear‐Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries

Small, EarlyView.
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E. Ingber, Zixiang Leonardo Liu, Netanel Korin   +10 more
wiley   +1 more source

Predictive Amphiphile Design Enables Control of Self‐Assembled Nanoparticle‐Cell Membrane Interactions

Small, EarlyView.
The interactions of self‐assembled nanocarriers with cell membranes are programmable through amphiphile design. We identify how head and tail chemistry govern distinct interaction mechanisms and introduce ΔGtransfer, a unified thermodynamic descriptor that predicts nanoparticle behaviour from simple molecular simulations.
Mahsa Nami, Tiffany Guitton‐Spassky, Farhad Sharif, Natalie Hanheiser, Riensqia Saudale, Jannik Gabriel, Aarti, Alireza Mirzaalipour, MohammadJavad Hafezi, Boris Schade, Abhishek Kumar Singh, Rainer Haag, Roland R. Netz, Hesam Makki   +13 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

A Critical Review of Resilient Modulus Characterisation in Unbound Granular Materials

International Journal of Pavement Research and Technology
Abstract The resilient modulus (M R ) is a fundamental parameter used to characterise the resilient response of unbound granular materials (UGMs), which are widely employed in the construction of flexible pavement systems.
Gabriel Rugabandana, Joseph Anochie Boateng, James Maina, Siya Rimoy   +3 more
openaire   +1 more source

From Nouns and Adjectives to Verbs: Base Effects on the Grammatical Behaviour of Denominal Verbs in Ancient Greek1

Transactions of the Philological Society, EarlyView.
Abstract This paper investigates the role of semantic features of noun and adjective bases in determining the grammatical behaviour of Ancient Greek denominal and deadjectival verbs in *‐ye/o‐. The paper adopts a lexicalist framework (Rappaport Hovav & Levin 1998) and examines how the event schema, actionality, telicity and voice of derived verbs are ...
Carolina Marescotti
wiley   +1 more source

FROM NY‐LON TO SILK? Shifting Centres of Attention in the World's Urban Fabric

International Journal of Urban and Regional Research, EarlyView.
Abstract This Interventions essay explores Silk Road urbanism's emergence as a rival to New York and London (NY‐LON) for global centre stage in Anglophone urban and regional studies. Through China's Belt and Road Initiative, more attention is being given to urban formations and associated new centralities beyond North Atlantic global/world cities ...
Tim Bunnell, Han Cheng, Wenn Er Tan
wiley   +1 more source

Contrastive ecoacoustic indices: Large‐scale global soundscape characterization with contrastive inference

Methods in Ecology and Evolution, EarlyView.
Abstract Ecoacoustics mainly aims at monitoring soundscapes by means of non‐invasive protocols. Despite the widespread adoption of machine and deep learning techniques, existing ecoacoustic models predominantly rely on supervised learning and, consequently, face two primary limitations: (1) the necessity of annotated data; and (2) the restriction to ...
Yann Teytaut, Sylvain Haupert, Lorenzo Dubois, Ludovic Crochard, Frédéric Azémar, Ángel G. Guevara, Patricia Balaresque, Jérôme Sueur   +7 more
wiley   +1 more source

A comprehensive review of the resilient behaviour of unbound granular pavement materials

Journal of Traffic and Transportation Engineering (English Edition)
Flexible pavements rely heavily on unbound granular materials for their base and subbase layers, where their performance under repetitive loading is critical. This performance is gauged by two main parameters: resilient modulus and permanent deformation, which are influenced by both intrinsic material properties such as gradation, moisture content, and
Ayesh Dushmantha, Shiran Jayakody, Yilin Gui, Chaminda Gallage   +3 more
openaire   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Three shades of self‐regulation with unique complex dynamics, drivers and targets for intervention

British Journal of Educational Technology, EarlyView.
Abstract Self‐regulated learning (SRL) is an active process involving multiple interacting components that evolve over time, exhibiting characteristics of complex systems such as non‐linearity, emergent behaviour, self‐organization, and hierarchy. These interactions unfold at different temporal levels, each warranting a dedicated lens to capture their ...
Sonsoles López‐Pernas, Miguel A. Conde, Mohammed Saqr   +2 more
wiley   +1 more source