Results 191 to 200 of about 742,712 (288)

Comparative assessment of volume‐of‐fluid (VOF) multiphase solvers for viscoplastic flow over grooved patterned surfaces

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Accurately simulating multiphase flows at low capillary numbers remains challenging due to spurious currents and interface discretization errors. We present a systematic comparison of four volume‐of‐fluid (VOF) solvers within the OpenFOAM framework for pressure‐driven Poiseuille–Bingham flow over grooved surfaces: interFoam with classical ...
Amir Joulaei, Alice Villette, Seyed Mohammad Taghavi   +2 more
wiley   +1 more source

High-accuracy pseudospectral scheme for fractional diffusion-wave problems based on cardinal functions. [PDF]

PLoS One
Saray BN, Juraev DA, Abdalla M, Efendiev R, Almalki Y, Ahdiaghdam S.   +5 more
europepmc   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Generation of multi-form exact wave solutions and linear stability analysis in the generalized (3+1)-D P-type plasma system using a modified extended mapping technique. [PDF]

Sci Rep
Ghayad MS, Ahmed HM, Badra NM, Rabie WB.
europepmc   +1 more source

Programmable hydrodynamics of active particles. [PDF]

Nat Commun
Rohde L, Anchutkin G, Holubec V, Cichos F.   +3 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Deciding for others diminishes model-based decision-making but depends on individual prosociality. [PDF]

NPJ Sci Learn
Huang Y, Du X, Zhen S.
europepmc   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Hypoellipticity of analytic differential operators in general ultradifferentiable classes. [PDF]

J Pseudodiffer Oper Appl
Fürdös S.
europepmc   +1 more source