Results 51 to 60 of about 3,561,056 (252)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Modeling Measurement Uncertainty in Room Acoustics

Acta Polytechnica, 2007
This paper investigates a way of determining and modeling uncertainty contributions in measurements of room acoustic parameters, which are commonly used to describe the acoustic situation of a room in an objective manner.
P. Dietrich
doaj  

Experimental Statistical Analysis of Tensile and Shear Properties of the Jute Fabric Epoxy Composites

Journal of Natural Fibers, 2022
The main objective of this study was to determine the mechanical properties and their analysis using uncertainty analysis of biodegradable Jute fabric composite.
Kumar Maharshi, Shivdayal Patel
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Modeling good research practices - overview: a report of the ISPOR-SMDM modeling good research practices task force - 1. [PDF]

, 2012
Models—mathematical frameworks that facilitate estimation of the consequences of health care decisions—have become essential tools for health technology assessment.
Briggs, Andrew H., Kuntz, Karen M., Kuntz, K.M., Siebert, Uwe, Briggs, A.H., Caro, J. Jaime, Siebert, U., Caro, J.J.   +7 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Joint clearing mechanism for the spot and ancillary service markets considering demand response resource allocation

Zhejiang dianli
Incorporating demand response （DR） resources as frequency regulation resources into the frequency regulation ancillary service market can further optimize resource allocation and improve resource utilization efficiency.
HE Yubin, GU Huijie, PENG Chaoyi, HU Yaping, NIE Yongquan, LAI Kaiting, PU Guilin   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A Hybrid Fuzzy DEMATEL–DANP–TOPSIS Framework for Life Cycle-Based Sustainable Retrofit Decision-Making in Seismic RC Structures

Mathematics
Seismic retrofitting of reinforced concrete (RC) structures is essential for improving resilience and extending service life, particularly in regions with outdated building codes.
Paola Villalba, Antonio J. Sánchez-Garrido, Lorena Yepes-Bellver, Víctor Yepes   +3 more
doaj   +1 more source