Results 81 to 90 of about 25,679,411 (340)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Uncertainty quantification for kinetic models in socio-economic and life sciences

, 2017
Kinetic equations play a major rule in modeling large systems of interacting particles. Recently the legacy of classical kinetic theory found novel applications in socio-economic and life sciences, where processes characterized by large groups of agents ...
A Chertock, A Dimits, ABT Barbaro, ABT Barbaro, B Düring, B Düring, B Yan, C Buet, C Buet, C Cercignani, C Chainais-Hillairet, D Matthes, D Xiu, D Xiu, D Xiu, DA Dunavant, E Cristiani, E Sonnendrucker, EW Larsen, F Cucker, F Filbet, G Ajmone Marsan, G Albi, G Albi, G Albi, G Albi, G Dimarco, G Dimarco, G Furioli, G Poëtte, G Toscani, G Toscani, H Cho, HL Scharfetter, J Hu, J Hu, JA Carrillo, JA Carrillo, JA Carrillo, JA Carrillo, JA Carrillo, JS Chang, L Pareschi, L Pareschi, M Ballerini, M Bennoune, M Bessemoulin-Chatard, M Bongini, M Burger, M Lemou, M Mohammadi, MB Giles, MR D’Orsogna, N Crouseilles, N Crouseilles, O Maitre Le, P Degond, P Pettersson, P Pettersson, R Duan, RE Caflisch, S Boscarino, S Cordier, S Gottlieb, S Jin, S Jin, S-Y Ha, S-Y Ha, SM Ahn, T-P Liu, Y Katz   +70 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

An Effective and Practical Probabilistic Simplified Neutrosophic Approach for Accurate and Reliable Innovative Design Evaluation for Digital Media Arts [PDF]

Neutrosophic Sets and Systems
The evaluation and classification of digital artworks remain a challenging task due to the inherent uncertainty, subjectivity, and imprecision in artistic design.
Yang Zhang, Yuzhuo Zhang
doaj   +1 more source

Enhance the Uncertainty Modeling Ability of Fuzzy Grey Cognitive Maps by General Grey Number

IEEE Access, 2020
In real-life systems, people cannot get precise data. The data are represented in the forms of interval or multiple intervals in many cases. Most intelligent algorithms are designed for precise data in algorithm research.
Jun Chen, Xudong Gao, Jia Rong
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A framework for modeling uncertainty in regional climate change [PDF]

, 2015
In this study, we present a new modeling framework and a large ensemble of climate projections to investigate the uncertainty in regional climate change over the United States (US) associated with four dimensions of uncertainty.
Gao, X, Monier, E, Schlosser, CA, Scott, JR, Sokolov, AP   +4 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Implementing Loss Distribution Approach for Operational Risk

, 2009
To quantify the operational risk capital charge under the current regulatory framework for banking supervision, referred to as Basel II, many banks adopt the Loss Distribution Approach.
Artzner, Aue, Basel Committee on Banking Supervision, Bedard, Berger, Böcker, Böcker, Böcker, Böcker, Bühlmann, Bühlmann, Chavez-Demoulin, Chernobai, Chernobai, Cont, Cruz, Dalla Valle, Degen, Efron, Embrechts, Embrechts, Embrechts, Embrechts, Embrechts, Ergashev, Frachot, Gerhold, Giacometti, Gilks, Gustafsson, Hess, Joe, Johnson, King, Klugman, Lambrigger, Lehmann, Lindskog, Luo, Luo, Marshall, McNeil, Mignola, Mignola, Nelson, Nešlehová, Panjer, Peters, Peters, Peters, Peters, Powojowski, Press, Robert, Sandström, Schaller, Shevchenko, Shevchenko, Shevchenko, Sundt, Wüthrich   +60 more
core   +2 more sources

Recursive Thick Modeling and the Choice of Monetary Policy in Mexico [PDF]

By following the spirit in Favero and Milani (2005), we use recursive thick modeling to take into account model uncertainty for the choice of optimal monetary policy.
Arnulfo Rodriguez, Pedro N. Rodriguez
core   +3 more sources