Results 41 to 50 of about 252,868 (269)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

A Hybrid Dropout Method for High-Precision Seafloor Topography Reconstruction and Uncertainty Quantification

Applied Sciences
Seafloor topography super-resolution reconstruction is critical for marine resource exploration, geological monitoring, and navigation safety. However, sparse acoustic data frequently result in the loss of high-frequency details, and traditional deep ...
Xinye Cui, Houpu Li, Yanting Yu, Shaofeng Bian, Guojun Zhai   +4 more
doaj   +1 more source

Solution-Space-Reduction-Based Evidence Theory Method for Stiffness Evaluation of Air Springs with Epistemic Uncertainty

Mathematics, 2023
In the Dempster–Shafer evidence theory framework, extremum analysis, which should be repeatedly executed for uncertainty quantification (UQ), produces a heavy computational burden, particularly for a high-dimensional uncertain system with multiple joint ...
Shengwen Yin, Keliang Jin, Yu Bai, Wei Zhou, Zhonggang Wang   +4 more
doaj   +1 more source

Mechanism Deduction from Noisy Chemical Reaction Networks

, 2018
We introduce KiNetX, a fully automated meta-algorithm for the kinetic analysis of complex chemical reaction networks derived from semi-accurate but efficient electronic structure calculations. It is designed to (i) accelerate the automated exploration of
Proppe, Jonny, Reiher, Markus
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Using Bayesian analysis to quantify and reduce uncertainty in experimental measurements — A narrow-angle radiometer case study

Measurement: Energy
Formal uncertainty analysis is an important but sometimes overlooked component of experimental work. Without quantified uncertainty, it is difficult to draw definitive conclusions from the experimental data, as a lack of formal uncertainty analysis ...
Teri S. Draper, Jennifer P. Spinti, Philip J. Smith, Terry A. Ring, Eric G. Eddings   +4 more
doaj   +1 more source

A Sensitivity Matrix Methodology for Inverse Problem Formulation [PDF]

, 2009
We propose an algorithm to select parameter subset combinations that can be estimated using an ordinary least-squares (OLS) inverse problem formulation with a given data set.
Banks, H. T., Capaldi, Alex, Cintron-Arias, Ariel, Lloyd, Alun L.   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Real-time data assimilation and control on mechanical systems under uncertainties

Advanced Modeling and Simulation in Engineering Sciences, 2021
This research work deals with the implementation of so-called Dynamic Data-Driven Application Systems (DDDAS) in structural mechanics activities. It aims at designing a real-time numerical feedback loop between a physical system of interest and its ...
Paul-Baptiste Rubio, Ludovic Chamoin, François Louf   +2 more
doaj   +1 more source