Results 251 to 260 of about 3,467,566 (283)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

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Global, regional, and national levels and trends in under-5 mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Inter-agency Group for Child Mortality Estimation

Lancet, The, 2015
Danzhen You, Daniel Hogan, Colin D Mathers   +2 more
exaly   +2 more sources

Under-5 Mortality

Encyclopedia of Evolutionary Psychological Science, 2021
openaire   +2 more sources

Maternal Age At Birth And Under-5 Mortality In Nigeria

East African Journal of Public Health, 2009
The paper examined the impact of maternal age at birth on under-5 death in Nigeria.Secondary data were generated from the 2003 Nigeria Demographic and Health Surveys in examining the relationship between maternal age at birth and under-5 mortality risk.
Titilayo , Ayotunde, Obiyan, Mary, Agunbiade, Ojo, Fasina, Fagbeminiyi   +3 more
openaire   +3 more sources

Levels and trends in under-5 mortality, 1990–2008

The Lancet, 2010
As global momentum and investment for accelerating maternal and child survival grows, monitoring of progress at the global and country level has become even more needed. Millennium Development Goal 4 (MDG 4) calls for a two-thirds reduction in the mortality rate among children under the age of 5 years between 1990 and 2015.
Danzhen, You, Tessa, Wardlaw, Peter, Salama, Gareth, Jones   +3 more
openaire   +2 more sources

New estimates of global under-5 mortality

The Lancet, 2007
Christopher Murray and colleagues publish the results of an analysis of under-5 mortality data. They note several issues they believe limit the quality and usefulness of evidence on child mortality estimates produced by the Inter-agency Child Mortality Estimation Group (IACMEG) which includes WHO UNICEF the World Bank the UN Population Division Harvard
openaire   +1 more source

Under 5 Child Mortality in the Maghreb countries.

La Tunisie medicale, 2020
Mortality, particularly at younger ages, is a key measure of population health.To describe under 5 children mortality trends and its related factors in the Great Maghreb countries over the last three decades 1994-2019.We conducted an observational descriptive study to clarify the situation in the Maghreb countries with regard to the under-five death ...
Nada, Boutrid, Sarra, Melki, Hakim, Rahmoune, Ahmed, Ben Abdelaziz   +3 more
openaire   +1 more source