Results 51 to 60 of about 1,454,799 (253)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Measuring and correcting bias in indirect estimates of under-5 mortality in populations affected by HIV/AIDS: a simulation study

BMC Public Health, 2019
Background In populations that lack vital registration systems, under-5 mortality (U5M) is commonly estimated using survey-based approaches, including indirect methods.
John Quattrochi, Joshua A. Salomon, Kenneth Hill, Marcia C. Castro   +3 more
doaj   +1 more source

Female labor force participation, paid maternity, caste system and under-5 mortality in Nepal [PDF]

Journal of Health Research, 2019
Purpose - The under-5 mortality rate in Nepal remains high in comparison to neighboring countries and developed nations. The result of this problem on Nepal’s social, economic, political and cultural development makes it an urgent priority requiring the ...
Kailash Timilsina, Yothin Sawangdee, Pojjana Hunchangsith, Jongjit Rittirong   +3 more
doaj   +1 more source

Spatio-temporal patterns of under 5 mortality in Nigeria

SSM - Population Health, 2018
•Under 5 mortality rates in Nigeria are very high. •There are significant variations in under 5 mortality rates across states over time. •There is evidence of statistically significant spatial autocorrelation over time. •Significant reductions are achievable with both state and region specific measures.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

LiST modelling with monitoring data to estimate impact on child mortality of an ORS and zinc programme with public sector providers in Bihar, India

BMC Public Health, 2018
Background Many interventions have attempted to increase vulnerable and remote populations’ access to ORS and zinc to reduce child mortality from diarrhoea. However, the impact of these interventions is difficult to measure.
Jayachandran A. Ayyanat, Catherine Harbour, Sanjeev Kumar, Manjula Singh   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

IJCM_149A: Profile of injuries among children admitted to a tertiary care hospital of Mangalore city, South India.

Indian Journal of Community Medicine
Background: Childhood injuries represent a significant public health concern worldwide, with a considerable impact on morbidity and mortality rates among children.
Siddharth Rathaur, Harika Lakshmi Polisetty, Roopkatha Ghosh, Faiza Hafiz, Nidhi Modi, Nithin Kumar, T Rekha, Bhaskaran Unnikrishnan, Prasanna Mithra, Ramesh Holla   +9 more
doaj   +1 more source

Prevalence of and factors associated with under-5 mortality in South Asia [PDF]

International Health, 2018
This study investigated the prevalence of and the factors associated with under-5 mortality across five South Asian countries.Cross-sectional pooled data from 1999 through 2014 collected from the Demographic and Health Survey (DHS) in five South Asian countries (Bangladesh, India, Maldives, Nepal and Pakistan) were used.
Hasan Sohail, Subas Neupane
openaire   +2 more sources