Results 141 to 150 of about 988,592 (311)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Children looked after away from home aged five and under in Scotland: experiences, pathways and outcomes. Insights for policymakers and practitioners [PDF]

, 2019
Statistics from 2018 (Scottish Government 2019) show that 14,738 children were looked after in Scotland (at 31st July 2018). Many children who become looked after away from home will return to their parents, but for some the decision is taken to ...
Bieha, Nina, Grant, Maggie, Hennessy, Alison, Cusworth, Linda, Whincup, Helen   +4 more
core  

Haemoglobin electrophoresis in under-fives of ekosodin community, Edo State, Nigeria

Sahel Medical Journal, 2011
Background: Sickle cell disease is the most common single gene disorder in Nigeria and most of West Africa. Morbidity and mortality associated with the disease is high hence the need for screening.
B l Abhulimhen-lyoha, M E Odunvbun, A A Okolo   +2 more
doaj  

Wealth-related inequalities in undernutrition among under-five children in sub-Saharan Africa

Scientific Reports
Undernutrition among under five children is a significant public health concern and a key factor in child mortality in developing nations. Addressing early childhood health disparities requires increased focus, as these issues are likely to persist into ...
Rahel Mulatie Anteneh, Natnael Moges, Asaye Alamneh Gebeyehu, Denekew Tenaw Anley, Ermias Sisay Chanie, Sintayehu Simie Tsega, Ermiyas Alemayehu, Melaku Ashagrie Belete, Natnael Kebede, Zufan Alamrie Asmare, Matyas Adugna, Zekaryas Ewnetu Gashu, Anteneh Mengist Dessie, Melkamu Aderajew Zemene   +13 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Children of mothers with physical disabilities : perceptions of parenting, the mother-adolescent relationship and the adolescent's engagement in risky behaviour : five case studies

, 2006
Includes bibliographical references (leaves [122]-132).This qualitative study investigated the effect of a mother's physical disability on the mother-adolescent relationship, parenting and the adolescent's engagement in risky behaviour.
Deglon, Under
core  

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source