Results 71 to 80 of about 37,865 (281)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluation of Dictionary Creating Methods for Under-Resourced Languages [PDF]

, 2017
In this paper, we present several bilingual dictionary building methods applied for Northern Saami–{English, Finnish, Hungarian, Russian} language pairs. Since Northern Saami is an under-resourced language and standard dictionary building methods require a large amount of pre-processed data, we had to find alternative methods. In a thorough evaluation,
Eszter Simon, Iván Mittelholcz
openaire   +1 more source

Crawl and crowd to bring machine translation to under-resourced languages [PDF]

Language Resources and Evaluation, 2016
We present a widely applicable methodology to bring machine translation (MT) to under- resourced languages in a cost-effective and rapid manner. Our proposal relies on web crawling to automatically acquire parallel data to train statistical MT systems if any such data can be found for the language pair and domain of interest.
Antonio Toral, Miquel Esplà-Gomis, Filip Klubicka, Nikola Ljubesic, Vassilis Papavassiliou, Prokopis Prokopidis, Raphael Rubino, Andy Way   +7 more
openaire   +3 more sources

Comparison of Different Orthographies for Machine Translation of Under-Resourced Dravidian Languages [PDF]

, 2019
Under-resourced languages are a significant challenge for statistical approaches to machine translation, and recently it has been shown that the usage of training data from closely-related languages can improve machine translation quality of these ...
McCrae, John P., John P. McCrae, Chakravarthi, Bharathi Raja, Mihael Arcan, Arcan, Mihael, Bharathi Raja Chakravarthi   +5 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Parsing under-resourced languages: Cross-lingual transfer strategies for Indian languages [PDF]

, 2014
Key to fast adaptation of language technologies for any language hinges on the availability of fundamental tools and resources such as monolingual/parallel corpora, annotated corpora, part-of-speech (POS) taggers, parsers and so on.
Ramasamy, Loganathan
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

End-to-end neural automatic speech recognition system for low resource languages

Egyptian Informatics Journal
The rising popularity of end-to-end (E2E) automatic speech recognition (ASR) systems can be attributed to their ability to learn complex speech patterns directly from raw data, eliminating the need for intricate feature extraction pipelines and ...
Sami Dhahbi, Nasir Saleem, Sami Bourouis, Mouhebeddine Berrima, Elena Verdú   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source