Results 51 to 60 of about 109,051 (284)
Advanced Science, EarlyView.This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang +12 more
wiley +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Brazilian Journal of Political Economy, 2007 This article is devoted to analyze changes in economic policy to be adopted by Mexico if a national development project were implemented. Starting from an evaluation of the main economic and political outcomes of Vicente’s Fox administration, the author ...
Arturo Guillén R.
doaj +1 more source
Advanced Science, EarlyView.Ba/Fe co‐doping and oxygen vacancy engineering synergistically modulate the Ru–O bond covalency in RuO2, leading to markedly enhanced OER activity across wide‐pH electrolytes. ABSTRACT Developing efficient and stable oxygen evolution reaction (OER) catalysts across a wide‐pH range is critical for practical water electrolysis.
Zongpeng Wang +10 more
wiley +1 more source
H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety
Advanced Science, EarlyView.Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou +12 more
wiley +1 more source
Circumventing Cultural Reification: A Study of Chimamanda Ngozi Adichie’S the Thing Around Your Neck
Romanian Journal of English Studies, 2014 Chimamanda Ngozi Adichie argues in her 2009 collection of short stories that in as much as brutal dictatorship together with extreme underdevelopment propel young Nigerians for immigration, inaccurate and often scandalizing media portrayal also has ...
Mami Fouad
doaj +1 more source
Advanced Science, EarlyView.Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang +15 more
wiley +1 more source
Some factors affecting the prosperity of trade in Ethiopia, 14th–18th Centuries
Cogent Arts & HumanitiesTrade has long been one of the significant economic activities in the Ethiopian region and the Horn of Africa. However, some challenges had been hampering the development and prosperity of the trade.
Mengistie Zewdu Tessema +1 more
doaj +1 more source
Exogenous underdevelopment pattern [PDF]
The main dynamics of capitalism is the creation of overproduction in order to search for an internal and foreign market outlet. While increasing the overproduction, both the expansion process and the internationalization of consumption raise. The context
Salvatore Michele De Marco
core
The underground economy and the underdevelopment trap [PDF]
, 2002 A general equilibrium model is proposed which assumes that firms hire both official and unregistered workers as imperfect substitutes, that entrepreneurs differ in their ability to increase the efficiency of official labour, and that this ability is due ...
Carillo, Rosaria, Pugno, Maurizio
core +1 more source