Results 41 to 50 of about 679,535 (248)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Assessment of Relative Utility of Underlying vs Contributory Causes of Death

JAMA Network Open, 2019
Importance: In etiological research, investigators using death certificate data have traditionally extracted underlying cause of mortality alone. With multimorbidity being increasingly common, more than one condition is often compatible with the manner of death.
Batty, G David, Gale, Catharine R, Kivimäki, Mika, Bell, Steven   +3 more
openaire   +7 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Studying the Degree of Diagnostic Agreement between Medical Records and Death Certificates in Loghman Hospital in 2005

مجله اپیدمیولوژی ایران, 2007
Background & Objectives: There is little doubt about the importance of accurate statistics and reliable information in the promoting community health and optimizing health care.
A Akbarzadeh Bagheban, E Maserat, M Hemmati   +2 more
doaj  

Diferenciais geográficos, socioeconômicos e demográficos da qualidade da informação da causa básica de morte dos idosos no Brasil Geographic, demographic, and socioeconomic differences in quality of data on cause of death in Brazilian elders

Cadernos de Saúde Pública, 2011
Identificaram-se diferenciais geográficos e socioeconômicos do padrão de qualidade da informação sobre a causa básica de morte dos idosos no Brasil.
Solange Kanso, Dalia Elena Romero, Iúri da Costa Leite, Edgar Nunes de Moraes   +3 more
doaj   +1 more source

Cause-specific mortality analysis: Is the underlying cause of death sufficient?

Revue Quetelet/Quetelet Journal, 2014
Resume L’analyse de la mortalite par cause repose principalement sur l’etude de la cause principale du deces. Notre point de vue est que cette approche n’est pas suffisante. Dans un nombre croissant de pays, toutes les causes reportees par les medecins sur les certificats de deces (ou «causes multiples») sont enregistrees et codees.
Désesquelles, Aline, Demuru, Elena, Egidi, Viviana, Frova, Luisa, Meslé, France, Pappagallo, Marilena, Salvatore, Michele Antonio   +6 more
openaire   +6 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

ASSESSMENT OF THE QUALITY OF ACCOUNTING OF DEATHS OF PATIENTS WITH MALIGNANT NEOPLASMS IN RUSSIA

Исследования и практика в медицине, 2016
It is presented the comparative assessment of the quality of the records of patients who died from malignant neoplasms (MN), according to the report of Rosstat used to calculate mortality rates (form No.
G. V. Petrova, V. V. Starinskiy, O. P. Gretsova   +2 more
doaj   +1 more source