Results 111 to 120 of about 2,738,424 (374)

Understanding and Explaining [PDF]

open access: yesAlmagest, 2012
The quest to provide a fundamental understanding and explanation of reality is an ambitious one. Perhaps it is too ambitious. The possible restrictions for such an enterprise to be successful must be inquired in order to determine the issue. Section 1 explores one’s understanding in reaching (scientific) conclusions: to what extent does a successful ...
openaire   +5 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

An Experiment of Evaluating Software Understandability [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2004
Software understandability is one of important characteristics of software quality because it can influence cost or reliability at software evolution in reuse or maintenance.
Shinji UCHIDA, Kazuyuki SHIMA
doaj  

Understanding the meaning [PDF]

open access: yesMonTi: Monografías de Traducción e Interpretación, 2009
En este artículo se realiza un repaso de la naturaleza del significado, con énfasis en el carácter asociativo de los significados léxicos. Igualmente, se comentan las dificultades semánticas que el traductor debe superar en múltiples ocasiones, ilustrándolas a través de textos de la Unión Europea, para poder alcanzar una interpretación coherente debido
openaire   +5 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Assessment of printed lung cancer surgery patient education materials in the United StatesCentral MessagePerspective

open access: yesJTCVS Open
Objective: Well-designed patient education materials (PEMs) increase health literacy, which has been linked to better surgical patient outcomes. The quality of lung cancer surgery PEMs is unknown, however.
Woorin Jang, BS   +10 more
doaj   +1 more source

FINANCIAL STATEMENTS UNDERSTANDABILITY BASED AN EXPLANATORY NOTES [PDF]

open access: yes
The present article is the result of the observation, analyses and personal conclusionsover the development of the IFRS at global level, their impact over the national and internationalcompanies all over the world and, nevertheless, the informational ...
Ana Morariu   +3 more
core  

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Residual Income in Four Dimensions: Goal-Congruity, Controllability, Understandability and Practicability [PDF]

open access: yes
The article discusses ten versions of residual income known in the literature from the point of view of four criteria that are of special importance if the measure is to be the basis of managerial bonuses: goal-congruity, controllability ...
Andrzej CWYNAR
core  

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy