FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Understanding Utterances an Introduction to Pragmatics
, 1992 viii, 191 hlm, 24 ...
Diane -Blakemore
core
Ab initio density response and local field factor of warm dense hydrogen
Matter and Radiation at ExtremesWe present quasi-exact ab initio path integral Monte Carlo (PIMC) results for the partial static density responses and local field factors of hydrogen in the warm dense matter regime, from solid density conditions to the strongly compressed case.
Tobias Dornheim +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Development of PhET-assisted Problem Based Learning Physics E-Book to Improve High School Learners' Concept Understanding [PDF]
The 21st century is an era where technology is increasingly advanced. Integrating technology in learning, especially physics, can increase student interaction in learning. 21st century skills cannot be achieved without concept understanding. It was found
Yasmin, Fathiyyah +3 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Association and Impact of Mathematics Anxiety Levels on the Quality of Students' Understanding Based on Skemp's Theory [PDF]
This study aimed to examine the association between math anxiety and students' comprehension quality based on Skemp's Theory and describe the impact of math anxiety level on students' comprehension quality.
Qothrunnada, Isni +1 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Enhancing Pre-Service Mathematics Teachers’ Conceptual Understanding Through Technology Integration: A Systematic Literature Review [PDF]
This systematic review analyzes the role of technology integration in improving the conceptual understanding of pre-service mathematics teachers based on the latest literature (2016–2025).
Ramdani, Rani Rizka, Hidayati, Kana
core +1 more source