Results 221 to 230 of about 10,888,923 (302)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Cognitive offloading and metacognitive calibration in generative AI-mediated doctoral learning: a grounded theory study of accountable reconstruction. [PDF]

Front Psychol
Gao L, Zhang F.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Public understanding of palliative care and preferences for place of end-of-life care and death: A national population-based latent class analysis. [PDF]

Palliat Care Soc Pract
Larsdotter C, Nyblom S, Imberg H, Sawatzky R, Öhlén J.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Patients' and healthcare professionals' experiences of malnutrition risk management in heart failure: a qualitative study. [PDF]

Front Nutr
Liu M, Xiong Z, Xu Y, Shen Q, Sun X, Liu S, Chen X, Xiong X.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Editorial: Harnessing genomics to revolutionize plant disease management and preservation of soil biodiversity. [PDF]

Front Microbiol
Tagele SB, Kassa AS, Tilahun S, Zegeye WA.   +3 more
europepmc   +1 more source

Navigating ICU Survival With a Temporary Tracheostomy. A Phenomenological Hermeneutic Study. [PDF]

Scand J Caring Sci
Akroute A, Brinchmann BS, Hovland A, Fredriksen STD.   +3 more
europepmc   +1 more source

PLEASURE UNDERSTANDING QUALITATIVE RESEARCH LEARNING.

, 1995
PLEASURE UNDERSTANDING TEAM
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