Results 141 to 150 of about 246,393 (287)

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

The winter 2023/2024 floods in the UK: a hydrological appraisal

Weather, EarlyView.
From October 2023 to March 2024, the UK saw a succession of named storms and low‐pressure weather systems, leading to widespread exceptional river flows throughout. Peak flow records were broken in several catchments, but this event was most notable for its duration and spatial footprint, which resulted in major impacts.
Eugene Magee, Rachael Armitage, Wilson Chan, Gayatri Suman, Amit Kumar, Lucy J. Barker, Stephen Turner, Jamie Hannaford, Catherine Sefton   +8 more
wiley   +1 more source

Between Sustainable Development, Financialisation and Sovereign Debt Crisis: The Case of Blue Finance as Yet Another Iteration of the Washington Consensus

Global Policy, EarlyView.
ABSTRACT As far as international economic law (IEL) is concerned, the ‘Washington Consensus’ generally refers to the World Bank and the International Monetary Fund (IMF)'s development finance policies and tools. It covers their application to their clients and borrowers with the support of Western governments. This acceptation is of particular interest
Leïla Choukroune
wiley   +1 more source

Movement Responses of Seals During Pile Driving for Offshore Wind Farm Construction

Animal Conservation, EarlyView.
Despite rapid growth of the renewable energy industry to meet climate change targets, predictions of population‐level impacts on wildlife are currently hindered by a limited understanding of individual behavioural responses to these developments.
Katherine F. Whyte, Gordon D. Hastie, Carol E. Sparling, Bas Binnerts, Debbie J. F. Russell   +4 more
wiley   +1 more source

Dispersal, source and glass chemistry of a third tephra unit within Iceland's Settlement Layer

Boreas, EarlyView.
Tephra layers may be studied to understand the dynamics and sequence of past explosive volcanism. In Iceland, the distinctive Settlement Layer (AD ~877) underlies almost all archaeological evidence for the Norse Settlement and is preserved in soils across Iceland and as cryptotephra overseas.
Conner A. G. Morison, Guðrún Larsen, Anthony J. Newton, Andrew J. Dugmore   +3 more
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Dynamic Wave Trains: A Procedural Approach to Spatially Varying Ocean Synthesis

Computer Graphics Forum, EarlyView.
In this paper, we present a high performance procedural model capable of synthesizing and rendering a virtually infinite ocean. Our method exhibits spatial variations as the orientations, speed and choppiness of the waves is parametrized for each frequencies and each point in space. The provided visual abstract exhibits a sunset rendering of a large 40 
Romain Fournier, Arthur Laurain, Pierre Kraemer, Guillaume Gilet, Basile Sauvage   +4 more
wiley   +1 more source

Scalable Computation of Topological Abstractions for Scalar Data

Computer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will, J. Lukasczyk, J. Tierny, A. Gyulassy, G. H. Weber, H. Carr, C. Garth   +6 more
wiley   +1 more source

Resolving three GABA induced electrogenic events and GABA‐coupling stoichiometry for Na+ and Cl− in hGAT‐1

The FEBS Journal, EarlyView.
Using solid‐supported membrane electrophysiology, we resolved three electrogenic events during GABA transport by the human GAT‐1 transporter. A rapid occlusion step (E1) is followed by a GABA‐induced Na+ leak current (E2), which becomes prominent under steep Na+ gradients, and a slower current associated with Na+‐coupled GABA transport (E3 ...
Rocco Zerlotti, Maria Barthmes, Kim Cole, Anna Mondini, Jean‐François Rolland, Niels Fertig, Christine Ziegler, M. Gregor Madej, Andre Bazzone   +8 more
wiley   +1 more source