Results 31 to 40 of about 96,420 (244)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

ACTAE regional project Accompanying the Agro-ecological Transition in Southeast Asia 2015 - 2019 Final report [PDF]

, 2019
L'agro-écologie répond à de nombreuses définitions relevant à la fois de dimensions scientifiques, environnementales et sociétales. Selon la littérature, les techniques qui lui sont attribuées concernent l'agriculture de conservation, l'agroforesterie ...
Marquié, Catherine, Reynaud, Lucie
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Planting and replanting: Continuity and change over four decades of forest restoration in Himachal Pradesh, India

Plants, People, Planet
India has a long history of planting trees to restore ecosystem services providing an opportunity to evaluate long‐term ecosystem restoration processes.
F. Fleischman, Pushpendra Rana, Harry W Fischer, Vijay Guleria, Rajesh Rana, V. Ramprasad   +5 more
semanticscholar   +1 more source

Experimenting with the design of policies on sustainable resources management : Phase 1 final report, January 2004 - February 2005 [PDF]

, 2005
The overall objective of the DMP is to arrest land degradation in Africa's desert margins through demonstration and capacity building activities. The GEF increment to this project will enable the programme to address issues of global environmental ...
Leclerc, Grégoire
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

La restauration des lacs au Québec: un défi face aux problèmes environnementaux actuels [PDF]

, 1997
Le Canada possède l'une des plus importantes réserves d'eau douce au monde. La province de Québec n'y fait pas exception puisqu'on y trouve près de 750 000 lacs et une multitude de rivières.
Dupont, J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ten golden rules for restoration to secure resilient and just seagrass social‐ecological systems

Plants, People, Planet
Seagrass meadows are a globally important habitat subject to significant loss. As efforts to restore these sensitive habitats are hampered by their high cost and low levels of reliability, rigorous guidance is required to improve effectiveness and ensure
R. Unsworth, B. L. Jones, C. M. Bertelli, Lucy Coals, L. Cullen‐Unsworth, A. Mendzil, S. C. Rees, Flo Taylor, Bettina Walter, Ally J. Evans   +9 more
semanticscholar   +1 more source