Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Overcoming ecological feedbacks in seagrass restoration
Overcoming ecological feedbacks is a major limiting factor reducing the success of many seagrass restoration projects. Negative feedbacks occur when biotic or abiotic conditions of a site are changed sufficiently after the loss of seagrass to prevent its
R. Unsworth +6 more
semanticscholar +1 more source
Seed germination of seven desert plants and implications for vegetation restoration
In this paper, we evaluated the seed germination responses of seven desert species to temperature and light and explored the implications for vegetation restoration.
L. Lai +5 more
semanticscholar +1 more source
Localizing the latent structure canonical uncertainty: Entropy profiles for hidden Markov models [PDF]
Ce rapport concerne l'inférence sur les états de modèles de Markov cachés. Ces modèles se fondent sur des états non observés, qui ont en général une interprétation, dans le contexte d'une application donnée. Ceci rend nécessaire la conception d'outils de
Durand, Jean-Baptiste, Guédon, Yann
core
Reconstituting a rainforest patch in southern Benin for the protection of threatened plants [PDF]
In a twenty-year effort at Drabo, southern Benin, small remnant forests, young fallow and agricultural fields were linked and rehabilitated to develop a 14 ha forest reserve.
Adomou, A.C., Neuenschwander, P.
core +4 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Impacts of Invasive Plants on Soil Fungi and Implications for Restoration
Biological plant invasions impact the function and biodiversity of ecosystems across the globe by displacing native plant species and altering the physical and chemical soil environment.
Brooke Pickett, M. Maltz, E. Aronson
semanticscholar +1 more source
Génie végétal contre l'érosion des berges de cours d'eau dans un contexte de changement climatique : quelles nouvelles espèces utiliser ? [PDF]
National audienceL'érosion des berges est un phénomène naturel participant activement aux processus de dynamique fluviale. Toutefois, afin de protéger des enjeux riverains (habitations, infrastructures de transport,) il est parfois nécessaire de fixer ...
Brahic, P. +3 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The water conservation capacity of the litter and soil layers of forest ecosystems improves the function of forest ecosystems in conserving soil and water. Plantation restoration plays a key role in preventing soil erosion. In order to evaluate the water
Suyi Chen +8 more
semanticscholar +1 more source

