Results 61 to 70 of about 96,420 (244)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Guiding seed movement: environmental heterogeneity drives genetic differentiation in Plathymenia reticulata, providing insights for restoration

AoB Plants
Forest and landscape restoration is one of the main strategies for overcoming the environmental crisis. This activity is particularly relevant for biodiversity-rich areas threatened by deforestation, such as tropical forests.
T. A. Conceição, A. S. Santos, A. K. C. Fernandes, Gabriela Nascimento Meireles, Fernanda Ancelmo de Oliveira, R. M. Barbosa, F. Gaiotto   +6 more
semanticscholar   +1 more source

Ellalou Dimmock Honors Voice Recital, November 13, 2012 [PDF]

, 2012
This is the concert program of the Ellalou Dimmock Honors Voice Recital performance on Tuesday, November 13, 2012 at 8:00 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Constraints of commercially available seed diversity in restoration: Implications for plant functional diversity

Plants, People, Planet
Large quantities of diverse native seeds are required to scale up global restoration efforts. However, it remains unclear for many ecosystems how the diversity of available seed in commercial stocks reflects the composition of the ecosystems where ...
Samantha E. Andres, Joe Atkinson, David Coleman, James Brazill‐Boast, Ian J. Wright, Stuart Allen, Rachael V. Gallagher   +6 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Changes in Soil Aggregate Carbon Components and Responses to Plant Input during Vegetation Restoration in the Loess Plateau, China

Plants
Vegetation restoration is an effective measure to cope with global climate change and promote soil carbon sequestration. However, during vegetation restoration, the turnover and properties of carbon within various aggregates change.
Yaoyue Liang, Jingbo Fang, Wenjing Jia, Shijie Wang, Hanyu Liu, Weichao Liu, Qi Zhang, Gaihe Yang, Xinhui Han, Guangxin Ren   +9 more
semanticscholar   +1 more source

Microgreffage de quatre espèces ligneuses sahéliennes (Acacia senegal, Faidherbia albida, Tamarindus indica et Ziziphus mauritiana) en vue de leur rajeunissement [PDF]

, 2001
Cette note décrit une méthodologie de rajeunissement pour quatre ligneux sahéliens: Acacia senegal, Faidherbia albida, Tamarindus indica, Ziziphus mauritiana.
Ba, S., Danthu, Pascal, De Troyer, Marie-Anne, Hane, B., Sagna, Maurice, Sagna, P., Soloviev, Pierre, Touré, M.   +7 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source