Results 81 to 90 of about 1,806,850 (248)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
LA Integración Económica de la Unión Europea, evolución y perspectivas [PDF]
, 2013 La Unión Europea (UE), es la única Unión Económica que existe en el mundo. En tal sentido, en el presente artículo analizamos la evolución histórica de la instauración de la Unión Europea, del mismo modo, analizamos el funcionamiento de la Unión Europea ...
Arteaga Velázquez, Gabriela María +1 more
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
, 2009 Financiación de la Unión Europea mediante un plan de recuperación ...
Milán Velasco, Margarita
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gaceta TécnicaEn esta investigación se tuvo como objetivo evaluar las propiedades físicas y mecánicas de ladrillos utilizando lodos residuales provenientes de plantas de tratamiento de agua potable y de tratamiento de aguas residuales.
Nicool Betsabe Orostegui Melendrez +2 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Evaluacion de la union adhesiva en la fabricacion de tableros contrachapados de grado exterior ignifugados [PDF]
, 2003 100 p.En este estudio se confeccionaron tableros contrachapados con chapas tratadas con un producto retardarte de llama (Stop-fire), unidas con un adhesivo fenolico, (Oxilite 2200), con el objetivo de obtener una unión satisfactoria en la conformación de
Gomez Lopez, Alonso +1 more
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source