Results 21 to 30 of about 63,080 (267)

EUSALP: "Presenta" tu proyecto para el concurso de la Unión Europea [PDF]

open access: yes, 2019
El ISSN corresponde a la versión electrónica del documentoEn el foro de este año de EUSALP en Innsbruck, Austria, se dio la oportunidad a jóvenes (de 16-25 años) de «presentar» ideas sobre proyectos innovadores ante un público de más de setecientas ...
Comisión Europea. Dirección General de Política Regional y Urbana
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

La educación y la formación permanentes: un reto para cada ciudadano

open access: yesRevista Española de Pedagogía
The European Year devoted to education and lifelong learning is intended to be one more step towards public awareness of the relevance of education and lifelong learning not only to Europe but also to every European citizen.
Edith Cresson
doaj   +1 more source

La Carta de Niza y la Europa de los ciudadanos. Apostillas a la carta de los derechos fundamentales de la Unión Europea [PDF]

open access: yes, 2002
SUMARIO: 1. Planteamiento: Hacia la constitución europea.-2. Elaboración y proclamación de la carta de Niza.-3. Una declaración de derechos para reforzar la Unión: Naturaleza y ámbito de la Carta.-4. Sistemática y contenido de la Carta.-5.
Pérez Luño, Antonio Enrique
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Participación argentina en inspecciones antárticas: ¿actividades esporádicas o ejercicios regulares

open access: yesCuadernos de Política Exterior Argentina, 2023
El objetivo de este trabajo es poder ofrecer una mirada estadística, comparativa e histórica, sobre la participación argentina en inspecciones del Sistema del Tratado Antártico, la importancia de haber alcanzado regularidad en su realización, así como ...
Rodrigo Conde Garrido
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek   +18 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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