Results 81 to 90 of about 1,697 (247)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Il ruolo dell’istruzione nautica nell’Italia meridionale dal Settecento a oggi
Nuova Antologia MilitareThe Kingdom of Naples at the arrival of Charles of Bourbon (1734) regained its independence, inaugurating a period of reformism in the civil and social sphere.
Maria Sirago, Mario Rastrelli
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Вестник Северного (Арктического) федерального университета: Серия «Гуманитарные и социальные науки»The article analyses the formation and construction of Islamic religious identity in Indonesia, which, according to the author, began in the second half of the 20th century.
Vladislav V. Bezmenov
doaj +1 more source
Bulletin of the Institute of Law of the Bashkir State University, 2019 This paper discusses the study of the method used in civil, tax and other financial relations to ensure the proper enforcing obligations (guarantees). In spite the tendency of unification of legal institutions, in the legislation of the Russian Federation there are still different types of guarantees: bank guarantee, independent guarantee, state ...
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
RUDN Journal of Law, 2013 The right of the USA doesn't contain legal definition of the legal entity (corporation), establishing only its main signs. The main thing from them is independence of existence of the legal entity and his participants, allowing it to enter on its own ...
J E Weizman
doaj
Kult św. Jozafata Kuncewicza w Kościele rzymskokatolickim w Polsce – między religią a ideologią
PolitejaThe Cult of St. Jozaphat Kuntsevych in the Roman Catholic Church in Poland – Between Religion and Ideology The figure of Josaphat Kuntsevych – a martyr of the Greek Catholic Church, proclaimed a saint of the Catholic Church – is of interest primarily to
Denys Pilipowicz
doaj +1 more source