Results 41 to 50 of about 167,597,506 (201)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Political Experience in Economic and Social Transformation
Wirtschaftsdienst, 2021 This article outlines the political events related to German unification on the occasion of its 30th anniversary. The revolutionary upheaval of 1989-90 led to the formulation of common economic and social models in the former Eastern bloc countries.
Christoph Bergner
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
20 Years of German Unification: Evidence on Income Convergence and Heterogeneity [PDF]
We analyse the convergence and heterogeneity of living standards between East and West Germany since unification. Based on data from the German Socio-Economic Panel (GSOEP), we compare total individual income of permanent adult residents, including ...
Heiko Peters, Tilman Brück
core +4 more sources
There is no Peace without War. Decorations of the Upper Lusatian Commemoration Hall façade
Potestas. Estudios del Mundo Clásico e Historia del Arte, 2020 The Upper Lusatian Commemoration Hall in which Emper-or-Friedrich-Museum is placed was erected in 1898-1904, according to a design by Hugo Behr, to commemorate the two Emperors who died in 1888 – Wilhelm I and his son, Friedrich III,
Marta Ostrowska-Bies
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the 'Burden' of German Unification: The Economic Consequences of Messrs. Waigel and Tietmeyer [PDF]
This paper investigates the causes of western Germany's remarkably poor performance since 1992. The paper challenges the view that the poor record of the nineties, particularly the marked deterioration in public finances since unification, might be ...
Jörg Bibow
core +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Raumforschung und Raumordnung, 1999 The author begins by setting out some of the underlying conditions which have shaped the current spatial planning situation in Germany. He criticises the fact that discussion on the way forward for spatial planning has taken place largely without ...
Karl-Hermann Hübler
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source