Results 51 to 60 of about 1,898 (226)

The Kernel Ontology Principle: Foundations for a Unified Fundamental Equation

⚠️ IMPORTANT UPDATE: NEWER VERSION AVAILABLE Please note that an updated version of this manuscript is available. Readers are encouraged to refer to the latest version for the most current definitions and formulations. https://doi.org/10.5281/zenodo.17654165 AbstractThis work presents the Kernel Ontology Principle (KOP), a foundational proposal in ...
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Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Unity of Truth - Foundational Charter and Unified Ontology of the UoT Foundation

This document presents the Unity of Truth Charter in its updated canonical form.It is grounded in the four logical constraints of any coherent and intelligible universe  (L0): Non-Contradiction (NC), Finite Information (FI), Finite Causal Grounding (CG), and Minimal Irreversibility (MI).
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A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Macrophage Membrane‐Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1‐ApoE Signaling in Diabetic Wounds

Advanced Healthcare Materials, EarlyView.
Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu, Yuan Xiong, Li Lu, Han Wang, Hui Hu, Mohammad‐Ali Shahbazi, Guohui Liu, Bobin Mi   +7 more
wiley   +1 more source

Frequency as the Foundation: A Unified Process Ontology of Reality

This document introduces a novel process ontology, proposing that reality is fundamentally a dynamically self-generating and self-organizing system. This intrinsic, irreducible drive towards self-organization through continuous activity is termed Autaxys.
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Merger of Critical Realism and Complexity Theory: Laying the Foundations for a Unified Ontological and Epistemological Perspective for the Study of Social Systems

Foundations of Science
Abstract This paper endeavors to engage Complexity Theory (CT) and Critical Realism (CR) in a constructive dialogue, aiming to build bridges between the two epistemological premises. CT, as a new perspective, is being endorsed in various fields, including the social sciences, where a shift from a linear, mechanistic and reductionist view ...
Maria Gkevrou, Dimitrios Stamovlasis
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Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Toward a Unified Field Theory of Narrative Agency: Reconstructing the Conceptual Foundations of Literary Ontologies

This paper proposes the development of a unified field theory for narrative agency, aiming to reconstruct the conceptual foundations of literary ontologies. Drawing inspiration from the pursuit of grand unification in physics, we seek to integrate diverse perspectives on agency within narrative, encompassing authorial intent, character autonomy, reader
Revista, Zen, LITERATURE, 10
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Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source