Results 81 to 90 of about 245,364 (303)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Understanding technology adoption and use by healthcare proferssionals using models of technology acceptance and q-methodology [PDF]

, 2017
This study explores the use of models of technology acceptance (TAM and UTAUT) to understand technology adoption and use among healthcare professionals (HCPs) in the clinical area in Sub-Saharan Africa (SSA).
Ladan, Muhammad Awwal, Wharrad, Heather, Windle, Richard   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Study of Consumer Behavior in Adoption of Technology-Based Product [PDF]

, 2007
This paper aims at describing factors that influence consumer intention to use new technology and how these factors interact with each other. The Academic Information System of the School of Business and Management ITB was selected as the unit of ...
Fachira, I. (Ira), Nasution, R. A. (Reza)   +1 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

What motivates posting online travel reviews? Integrating gratifications with technological acceptance factors

Tourism and Hospitality Management, 2019
Purpose –The aim of the present study is to understand the effect of travelers’ motivations and technological acceptance factors on intentions to post online reviews.
Shuchita Bakshi, Nikita Dogra, Anil Gupta   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Applying extended UTAUT model to examine microlearning adoption: An Empirical study of Vietnamese Telecommunication Companies [PDF]

Zbornik radova Ekonomskog fakulteta u Rijeci : časopis za ekonomsku teoriju i praksu
This paper extends the UTAUT model to examine microlearning adoption in the Vietnamese telecommunication industry. A self-administered survey was implemented to collect data from the three biggest Vietnamese telecommunication companies. After two months,
Bui Quang Tuyen, Phuong Mai Nguyen
doaj   +1 more source

Explaining intention and use of Mhealth with the unified theory of acceptance and use of technology

Acta Psychologica
mHealth can alleviate the pressure on healthcare. However, its adoption is limited, especially among low socioeconomic groups. Identifying factors that influence the intention to and actual use of mHealth is crucial to increase adoption.To identify factors influencing intention and use of mHealth apps among Dutch adults, focusing on various ...
van de Werken, Hermanus A., Rohrbach, Pieter J.; id_orcid 0000-0003-0795-466X, Bolman, Catherine A.W.; id_orcid 0000-0001-9209-6449   +2 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source