Results 31 to 40 of about 1,554,505 (255)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Abstract and Applied Analysis, 2013 This paper is devoted to investigate the fixed points and best proximity points of multivalued cyclic self-mappings on a set of subsets of complete metric spaces endowed with a partial order under a generalized contractive condition involving a Hausdorff
M. De la Sen
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Application of Pettis integration to delay second order differential inclusions
Electronic Journal of Qualitative Theory of Differential Equations, 2012 In this paper some fixed principle is applied to prove, in a separable Banach space, the existence of solutions for delayed second order differential inclusions with three-point boundary conditions of the form $$\ddot u(t)\in F(t,u(t),u(h(t)),\dot u(t ...
D. Azzam-Laouir +2 more
doaj +1 more source
Uniformly bounded set-valued composition operators in the spaces of functions of bounded variation in the sense of Wiener [PDF]
, 2015 We show that the one-sided regularizations of the generator of any uniformly bounded set-valued Nemytskij composition operator mapping the space of bounded variation functions in the sense of Wiener into the space of bounded variation functions with ...
Matkowski, J. +3 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Entire functions uniformly bounded on balls of a Banach space [PDF]
, 2011 Let X be an in finite-dimensional complex Banach space. Very recently, several results on the existence of entire functions on X bounded on a given ball B1 X and unbounded on another given ball B2 X have been obtained.
Ponte Miramontes, María Del Socorro +6 more
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
پژوهشهای ریاضی, 2018 Introduction Let be a nonempty subset of a normed linear space . A self-mapping is said to be nonexpansive provided that for all . In 1965, Browder showed that every nonexpansive self-mapping defined on a nonempty, bounded, closed and convex subset of
Moosa Gabeleh
doaj