Results 51 to 60 of about 1,141,927 (320)

Digital Competitiveness in the European Union Era: The Greek Case

open access: yesEconomies, 2020
Digital competitiveness is gaining more and more attention as a source of competitive advantage at the business and national economies levels. Digital economy performance is a matter of national strategies for achieving economic growth and socioeconomic ...
Eleni Laitsou   +2 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Progress in Implementing Capacity-Building Provisions under the Labor Chapter of the Dominican Republic – Central America – United States Free Trade Agreement [PDF]

open access: yes, 2009
[Excerpt] Section 403(a) of the CAFTA-DR Implementation Act includes a reporting requirement on labor issues related to the CAFTA-DR. Specifically, that section requires the President to submit a biennial report to Congress on the progress made by the ...
Bureau of International Labor Affairs
core   +4 more sources

Sustainable Development in the Digital Age: Harnessing Emerging Digital Technologies to Catalyze Global SDG Achievement

open access: yesApplied Sciences
The digital revolution, characterized by rapid technological advancements, presents a unique opportunity to accelerate progress towards the United Nations’ Sustainable Development Goals (SDGs).
Claudiu George Bocean
doaj   +1 more source

Corporate liability for environmental harm [PDF]

open access: yes, 2010
Book synopsis; This wide-ranging and comprehensive Handbook examines recent developments in international environmental law (IEL) and the crossover effects of this expansion on other areas of public law, such as trade law and law of the sea.
Perry-Kessaris, Amanda
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Soviet Documentary Films in Lithuania: Historical and Ideological Contexts (1963–1988)

open access: yesGenocidas ir Rezistencija, 2005
The entire cinematography and documentary film production of the Soviet Union often created an analogue a country leading an autonomous life on the screen.
Irina Černeckaitė
doaj   +1 more source

European Union Social Policy as an Instrument for Sustainable Development [PDF]

open access: yes, 2010
This paper undertakes an analysis and assessment of European Union (EU) social policy in the context of the sustainability of the group's social and economic development. The process of Europeanizing EU social policy is not advanced.
Witkowska Janina
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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